Loading interface...

Imicalm-2 Tablet

Manufactured byEast West Pharma
ContainsImipramine (25 mg) + Diazepam (2 mg)
Description
Imicalm-2 Tablet is a combination medicine that consists of imipramine and diazepam. It is an effective medicine used for the treatment of depression (a medical condition that affects your mood). It helps in regulating the mood and behavioural changes thereby help in treating other psychiatric medical conditions. Imicalm-2 Tablet works by increasing the levels of a chemical substance in the brain called serotonin and helps in regulating mood and treats depression. Imicalm-2 Tablet may cause side effects like weight gain, tiredness, constipation, dry mouth, etc. Consult your doctor if these symptoms stay for a long time or if they become severe. This medicine may also cause dizziness and blurred vision. Hence do not drive or operate any machine during the treatment. Do not use this medicine if you are allergic to it. Imicalm-2 Tablet is not recommended for use in children below 12 years of age. Imicalm-2 Tablet can be taken as with or without food. The duration of treatment will be decided by your doctor based on the severity of your condition and other underlying diseases. Take this medicine at the same time every day and do not skip any dose or discontinue the treatment, as it may cause withdrawal symptoms such as anxiety, sleep disturbances, irritability, etc. Due to serious side effects, this combination medicine is banned in India. Imicalm-2 Tablet may not be suitable for all people. Inform your doctor if you have diabetes, liver, heart or kidney problem, or a history of seizures, glaucoma before taking this medicine. Close evaluation concerning your current medicines is necessary to avoid any undesired side effects. If you are pregnant, breastfeeding, or are planning a pregnancy consult your doctor before taking this medication.

Side effects

Major & minor side effects for Imicalm-2 Tablet

  • Abdominal pain
  • Blurred vision
  • Decrease in frequency of urination
  • Dry mouth
  • Rapid weight gain
  • Yellow colored eyes or skin
  • Unusual tiredness and weakness
  • Increased sensitivity of the eyes to sunlight
  • Skin rash
  • Constipation
  • Nausea or vomiting
  • Sense of imbalance
  • Headache
  • Sleepiness
  • Nervousness
  • Unsteady walk

Uses of Imicalm-2 Tablet

What is it prescribed for?

  • Depression
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The onset of action for Imicalm-2 Tablet is not known.
  • How long do the effects of this medicine last?
    The duration of action for Imicalm-2 Tablet is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Imicalm-2 Tablet due to the increased risk of side effects such as dizziness, drowsiness, difficulty in concentration, etc.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported with Imicalm-2 Tablet.
  • Can this medicine be taken during pregnancy?
    Imicalm-2 Tablet is not recommended for use during pregnancy as it is known to cause serious side effects in the foetus. Your doctor may prescribe a safer alternative with the same therapeutic effect based on your condition.
  • Can this medicine be taken while breast-feeding?
    Imicalm-2 Tablet pass into the breastmilk and hence it is not recommended to be used in breastfeeding. Your doctor may prescribe a safer alternative with the same therapeutic effect based on your condition.

Allergy

Do not take Imicalm-2 Tablet if you are allergic to it. If you notice any symptoms such as a skin rash, itching/swelling anywhere on your body, dizziness, breathing difficulty, etc., seek medical attention immediately.

Monoamine oxidase inhibitors (MAOI)

Monoamine oxidase inhibitors are a class of medicines used to treat depression. Imicalm-2 Tablet is not recommended if you have taken MAOI within the last 14 days due to the increased risk of serious side effects.
Warnings for special population

Pregnancy

Imicalm-2 Tablet is not recommended for use during pregnancy as it is known to cause serious side effects in the foetus. Your doctor may prescribe a safer alternative with the same therapeutic effect based on your condition.

Breast-feeding

Imicalm-2 Tablet pass into the breastmilk and hence it is not recommended to be used in breastfeeding. Your doctor may prescribe a safer alternative with the same therapeutic effect based on your condition.
General warnings

Sedation

Use of Imicalm-2 Tablet can cause sedation and impairment of physical abilities. You should avoid doing activities that require mental alertness while using this medicine.

Suicidal tendencies

Imicalm-2 Tablet should be used with caution due to the increased risk of suicidal thoughts. Any unusual symptoms are changes in behaviour should be reported to your doctor immediately. Your doctor may monitor your condition closely while on treatment with this medicine.

Withdrawal symptoms

Do not stop the use of Imicalm-2 Tablet suddenly as it may result in withdrawal symptoms such as nausea and/or vomiting, headache, anxiety, dizziness, sleep disturbances, irritability, etc. Your doctor may adjust the dose of this medicine if required. Please consult your doctor.

Surgery

Use of Imicalm-2 Tablet is not recommended if you are planning to undergo surgery in the near future as it may cause serious side effects. Consult your doctor.

Bipolar disorder

Imicalm-2 Tablet is not recommended in bipolar disorder. Symptoms of mania and depression can worsen upon the usage of this medicine. Consult your doctor and report the incidence of bipolar depression or mania before receiving this medicine.

Drowsiness

Imicalm-2 Tablet may increase your risk of dizziness, sleepiness, or visual disturbances. If you experience such symptoms, avoid driving or operating machines.

Missed Dose

If you forget to take a dose of Imicalm-2 Tablet, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose to compensate for a missed one.

Overdose

Never take more than the prescribed dose. Overdose of this medicine may cause serious undesirable effects. Contact your doctor in case of an overdose with Imicalm-2 Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Imicalm-2 Tablet due to the increased risk of side effects such as dizziness, drowsiness, difficulty in concentration, etc.
Interaction with Medicine

Metoclopramide

Ondansetron

Antidiabetic medicines

Opioids

Azole antifungal agents

Antihypertensives

Disease interactions

Heart disease

Imicalm-2 Tablet should be used with caution if you have any heart problems like heart failure, stroke, heart block etc. A fall in blood pressure, changes in pulse, dizziness and other associated complications should be reported to the doctor on priority. It is not recommended for use if you had a heart attack recently.

Seizure disorders

Seizure is a condition in which there is disturbed nerve cell activity in the brain resulting in abnormal behaviour and loss of consciousness. Imicalm-2 Tablet may worsen your condition if you have a history of seizures and should be used with caution.

Liver disease

Imicalm-2 Tablet should be used with caution if you have pre-existing liver problems due to the increased risk of severe side effects. Your doctor may monitor your liver function if required based on your condition.

Kidney diseases

Imicalm-2 Tablet should be used with caution if you have kidney impairment due to an increased risk of worsening the condition. Your doctor may monitor your kidney function closely if required based on your clinical condition.

Obesity

Imicalm-2 Tablet should be used with caution in obesity because of the increased risk of central nervous system disorders. Your doctor may prescribe an appropriate dose based on your clinical condition.

Glaucoma

Glaucoma is a condition in which the optic nerve (the nerve connecting the eye to the brain) is damaged, usually due to high eye pressure. Imicalm-2 Tablet should be avoided if you have a history of glaucoma due to the increased risk of worsening your condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Imicalm-2 Tablet with or without food. Do not take more or less than the prescribed dose. Do not stop the use of this medicine without consulting your doctor as it may result in withdrawal symptoms. Imicalm-2 Tablet may increase your risk of suicidal thoughts. Consult your doctor if you experience any changes in mood or behaviour. Avoid consuming alcohol while taking Imicalm-2 Tablet, as it may cause severe drowsiness and dizziness. Do not drive or operate a machine if you experience any symptoms that may affect your alertness after taking Imicalm-2 Tablet. Inform your doctor if you are pregnant, breastfeeding or have any medical conditions like glaucoma, liver disease, kidney disease, heart problem. Keep the medicine out of reach of children. Do not use it after the expiry date. Any unused medication should be discarded properly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Imicalm-2 Tablet is a combination of Diazepam and imipramine. Diazepam works by increasing the action of GABA, a chemical messenger which suppresses the excessive activity of the nerve cells in the brain. Imipramine is an antidepressant that increases the levels of chemical messengers in the brain that help in regulating mood and treat depression.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Tricyclic antidepressants, Sedative hypnotics, Benzodiazepines, Antianxiety Agents

Schedule

Shedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Imipramine. [online] Available at: < [Accessed 14 September 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Imipramine>

Drugs, H., 2021. Diazepam: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 14 September 2021].

https://medlineplus.gov/druginfo/meds/a682047.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Diazepam. [online] Available at: < [Accessed 14 September 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/3016>

Medicines.org.uk. 2021. [online] Available at: < [Accessed 14 September 2021].

https://www.medicines.org.uk/emc/files/pil.5789.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 14 September 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/013263s083lbl.pdf>
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 14 Sep 2021

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.