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Imanib 100 mg Capsule

Manufactured by: Intas Pharmaceuticals Ltd.
Composition: Imatinib Mesylate
Prescription Required: Yes
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Description

Imanib 100 mg Capsule is used to treat and prevent the growth of certain types of cancers of the blood cells, stomach, intestine, bone marrow, and skin.

Side effects

Major & minor side effects for Imanib 100 mg Capsule

  • Diarrhea
  • Nausea and Vomiting
  • Mouth sores
  • Loss of appetite
  • Altered sense of taste
  • Heartburn and indigestion
  • Joint pain, stiffness, and swelling
  • Burning or tingling sensation of skin
  • Difficulty in falling or staying asleep
  • Skin rash, hives, or itching
  • Hair loss or thinning of the hair
  • Swelling around the eyessevere
  • Swelling or the hands, feet, ankle, and lower legssevere
  • Severe breathing difficultysevere
  • Fast/irregular heart beatsevere
  • Presence of blood in coughsevererare
  • Yellowing of skin and eyessevererare
  • Unusual bleeding or bruisingsevere
  • Abdominal pain or bloatingsevere
  • Bloody stoolsevererare
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Imanib 100 mg Capsule

Onset of action

The amount of time taken by this medicine to show its effect is subject to vary based on the intended use.

Duration of effect

The amount of time for which this medicine remains effective in the body is subject to vary based on the intended use and duration of use.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women unless absolutely necessary and the potential benefits outweigh the risks involved. Your doctor will determine the best course of treatment after assessing the clinical condition.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Substitutes

List of substitutes for Imanib 100 mg Capsule

Below is the list of medicines, which have the same composition, strength and form as Imanib 100 mg Capsule, and hence can be used as its substitute.
Ibatkin 100 mg Capsule
Zuventus Healthcare Ltd.
Imatib 100 mg Capsule
Cipla Ltd.
Imatib A 100 mg Capsule
Cipla Ltd.
Veenat 100 mg Capsule
Natco Pharma Ltd.

What is it prescribed for?

Uses of Imanib 100 mg Capsule

  • Chronic myelogenous leukemia (CML)

    This medicine is used for the treatment of a specific type of blood cancer where the bone marrow produces white blood cells in excessive quantities for a prolonged period of time.

  • Acute lymphoblastic Leukemia (ALL)

    This medicine is used for the treatment of a specific type of blood cancer where the bone marrow produces cancerous and immature lymphoblasts in large quantities. This also inhibits the growth and maturity of normal blood cells.

  • Myeloproliferative disorder

    This medicine is used for the treatment of a group of conditions that cause the red blood cells, white blood cells, and platelets to grow abnormally in the bone marrow.

  • Myelodysplastic disease

    This medicine is used for the treatment of a group of conditions where the newly formed blood cells in the bone marrow fail to mature, resulting in ineffective blood cell production.

  • Systemic mastocytosis

    This medicine is used for the treatment of a condition where the mast cells are abnormally increased in multiple organs including the bone marrow. This results in excessive production of mediators such as histamine in the body. This may result in symptoms similar to an allergic reaction.

  • Hypereosinophillic syndrome

    This medicine is used for the treatment of a condition characterized by persistently elevated levels of eosinophil cells in the blood without any recognizable cause.

  • Chronic eosinophillic leukemia

    This medicine is used for the management of a condition where the levels of eosinophils are significantly high in the bone marrow and the blood for a prolonged duration of time.

  • Dermatofibrosarcoma protuberans

    This medicine is used for the treatment of a very rare cancer of the skin.

  • Gastrointestinal stromal tumor

    This medicine is used for the treatment of tumors that start in the walls lining the stomach and the intestine.

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When not to use?

Contraindications of Imanib 100 mg Capsule

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to imatinib or any other inactive ingredients present along with it.

Dosage

  • Missed Dose

    Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Contact your doctor for further instructions if you miss more than one scheduled dose of this medicine.

  • Overdose

    Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms may include nausea, vomiting, diarrhea, skin allergies, tiredness, fever, etc.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Disease interactions

  • Heart and blood vessel disorder

    moderate
    This medicine should be used with caution in patients having a disease of the heart or the blood vessels due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is recommended for such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

  • Fluid Retention and edema

    moderate
    This medicine should be used with caution in patients having fluid retention disorders due to the increased risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

  • Bone marrow suppression

    moderate
    This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Liver/kidney impairment

    moderate
    This medicine should be used with caution in patients suffering from a disease of the liver or the kidneys due to the increased risk of severe side effects. Appropriate dose adjustments and frequent clinical monitoring are advised in such cases. Replacement with a suitable alternative may be required based on the clinical condition.

Food interactions

  • Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take Imanib 100 mg Capsule exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Do not take this medicine on an empty stomach. You may require frequent blood tests and liver function tests while taking this medicine. You may also require frequent followups with your doctor to check the progress of treatment. Do not stop the use of this medicine without consulting your doctor.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women unless absolutely necessary and the potential benefits outweigh the risks involved. Your doctor will determine the best course of treatment after assessing the clinical condition.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General warnings

  • Gastrointestinal disorders

    - This medicine should be used with caution in patients having a pre-existing disorder of the stomach or the intestine due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

  • Hypothyroidism

    - This medicine should be used with caution in patients having a low level of thyroid hormone due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid hormones is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Use in the elderly

    - This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects.

  • Other medicines

    - Since Imanib 100 mg Capsule may interact with many other medicines and may cause severe adverse effects, it is advised that you report the use of all other medicines including herbs and supplements to the doctor before beginning treatment with Imanib 100 mg Capsule.

  • Live attenuated vaccine

    - Report the administration of a live attenuated vaccine (smallpox, BCG, influenza, measles, rubella, etc.) to the doctor before treatment with Imanib 100 mg Capsule is initiated. Since Imanib 100 mg Capsule may alter the effects of the vaccines, your doctor may advise you to postpone therapy with the medicine based on your clinical condition.

  • Heart and blood vessel disorder

    - This medicine should be used with caution in patients having a disorder of the heart or blood vessels due to the increased risk of worsening of the patient's condition.

  • Fluid retention and edema

    - This medicine should be used with caution in patients suffering from fluid retention or edema due to the increased risk of worsening of the patient's condition.

  • Growth retardation

    - This medicine should be used with caution in children due to the increased risk of growth retardation. Close monitoring of growth parameters is advised during treatment with this medicine.

  • Dizziness and blurring of vision

    - Use of this medicine may cause dizziness and blurring of vision. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

  • Internal bleeding or hemorrhage

    - This medicine should be used with caution due to the increased risk of internal bleeding or hemorrhages. Any symptoms such as unusual bleeding or bruising, black or tarry stools, vomiting up blood, etc. should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Risk of infections

    - Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

Other details

  • To be taken with food
  • To be taken as instructed by doctor
  • May cause sleepiness

How it works

This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
BCR-ABL tyrosine kinase inhibitors
Schedule
Schedule H

References

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Information on this page was last updated on 15 Sep 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.