Idarubicin

Description

Idarubicin is an anticancer agent which is used in the treatment of various types of cancers of the blood. It should be used under the supervision of a qualified physician. Close monitoring of kidney, liver function and blood cell count is necessary while receiving this medication.

Side effects

Major & minor side effects for Idarubicin

  • Headache
  • Chills and fever
  • Hair loss or thinning of the hair
  • Loss of appetite
  • Nausea and vomiting
  • Red colored urine
  • Skin rash and itching
  • Darkening of skin
  • Tiredness and weakness

Uses of Idarubicin

What is it prescribed for?

  • Acute Lymphocytic Leukemia (ALL)
  • Acute Myeloid Leukemia
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use if you have a known allergy to idarubicin or any other ingredients present along with it.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.

Severe and uncontrolled infections

This medicine is not recommended for use in patients who have severe and uncontrolled infections due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Bonemarrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Risk of infections

Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while receiving this medicine.

Driving or Operating machinery

Use of this medicine may cause dizziness, tiredness, etc. in some patients. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.

Hyperuricemia

This medicine may elevate the blood uric acid levels in some patients. Close monitoring of blood uric acid levels is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Effect on heart

This medicine may increase the risk of toxic effects on the heart and could lead to severe adverse effects. Patients with a history of heart diseases need close monitoring while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient. This medicine is not recommended for use in patients with serum bilirubin greater than 5 mg/dL.

Kidney impairment

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient. This medicine is not recommended for use in patients with severe kidney impairment.

Missed Dose

Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session, contact your doctor immediately for further instructions. Capsule: Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected. Capsule: Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Calcium channel blockers

Live attenuated vaccines and related products

Azathioprine

Clozapine

Cyclosporine

Atorvastatin

Disease interactions

Bone marrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart disease

This medicine should be used with caution in patients having a disease of the heart due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is recommended for such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Hepatic impairment

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient. This medicine is not recommended for use in patients with serum bilirubin greater than 5 mg/dL.

Renal impairment

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient. This medicine is not recommended for use in patients with severe kidney impairment.
Food interactions
Information not available.
Lab interactions
Information not available.
Injection: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Capsule: Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by stopping the growth of cancer cells by inhibiting DNA synthesis.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Antineoplastics, Anthracyclines

Schedule

Schedule H

[Internet]. Mhra.gov.uk. 2018 [cited 12 December 2018]. Available from:

http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con793802.pdf

Idarubicin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 25 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a691004.html

[Internet]. Pfizer.com. 2018 [cited 12 December 2018]. Available from:

https://www.pfizer.com/files/products/uspi_idamycin.pdf

Zavedos 10 mg Capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 26 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/2847/smpc

[Internet]. Medicines.org.uk. 2018 [cited 12 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.2848.pdf

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Information on this page was last updated on 19 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.