Ibrutinib
Description
Ibrutinib is used for the treatment of a certain type of cancers that affects the blood cells and lymph nodes. It is also used to treat chronic graft vs host disease, a complication that might occur after a bone marrow transplant.
QUICK LINKS:
Side effects
Major & minor side effects for Ibrutinib
- Mouth sores
- Diarrhea
- Skin Rash
- Difficulty in breathing
- Back pain or Joint pain
- Unusual tiredness or weakness
- Muscle pain
- Dizziness
- High blood pressure
- Broken and brittle nails
- Headache
- Pale skin
Uses of Ibrutinib
What is it prescribed for?
- Chronic Lymphocytic Leukemia
- Mantle Cell Lymphoma
- Waldenstrom's Macroglobulinemia
- Marginal Zone Lymphoma
- Chronic graft-versus-host disease (cGVHD)
Read More
Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to ibrutinib or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Kidney impairment
This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Liver impairment
This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Heart diseases
This medicine should be used with caution in patients with heart diseases due to the increased risk of worsening of the patient's condition. Close monitoring of the heart function, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Bleeding
This medicine should be used with extreme caution in patients with a known risk of bleeding due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Infections
This medicine should be used with caution due to the increased risk of severe and potentially life-threatening infections. Report any unusual symptoms such as a fever, diarrhea, sore throat, pain or burning during urination, etc. to the doctor immediately. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases.
Use in children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.
Driving or operating machinery
Use of this medicine may cause dizziness, visual disturbances, and tiredness. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.
Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Isoniazid
Verapamil
Sitagliptin
Erythromycin
Miconazole
Azathioprine
Clopidogrel
Aspirin
Ketoconazole
Disease interactions
Atrial Fibrillation
This medicine should be used with extreme caution in patients with or a history of atrial fibrillation and other cardiac diseases like hypertension due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Liver impairment
This medicine should be used with extreme caution in patients with mild and moderate liver impairment due to the risk of worsening of the patient's condition. Close monitoring of liver function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases. This medicine is not recommended for use in patients with severe liver impairment.
Lung Toxicity
This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Kidney impairment
This medicine should be used with extreme caution in patients with mild to moderate kidney impairment due to the risk of worsening of the patient's condition. Close monitoring of kidney function is recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases.
Tumor Lysis Syndrome
This medicine should be used with extreme caution due to the increased risk of tumor lysis syndrome. This risk is especially higher in patients suffering from electrolyte abnormalities and kidney diseases. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Avoid consumption of grapefruit or grapefruit juice and Seville oranges while taking this medicine since it may cause severe adverse effects. Report to your doctor, if you experience any adverse effects such as irregular heart rhythm, diarrhea, nausea, vomiting, abdominal pain, and high blood sugar, etc.
Lab interactions
Information not available.
Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
Legal Status
Classification
Category
Antineoplastics, Multikinase inhibitors
Schedule
Schedule H
DailyMed - Imbruvica - ibrutinib capsule - ibrutinib tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 14 August 2019]. Available from:
[Internet]. Medicines.org.uk. 2018 [cited 11 December 2018]. Available from:
Ibrutinib - DrugBank [Internet]. Drugbank.ca. 2019 [cited 14 August 2019]. Available from:
Ibrutinib: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 14 August 2019]. Available from:
Information on this page was last updated on 16 Aug 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.