Hyoscyamine

Description

Hyoscyamine is an alkaloid derivative used for the treatment of various gastrointestinal disorders including spasms such as peptic ulcer, irritable bowel syndrome, etc. It is also used to relieve the tremors in patients with parkinsonism.

Side effects

Major & minor side effects for Hyoscyamine

  • Dry skin
  • Constipation
  • Difficulty in swallowing
  • Blurred vision
  • Increased heartrate
  • Headache
  • Loss of taste
  • Nervousness

Uses of Hyoscyamine

What is it prescribed for?

  • Parkinsonian tremor
  • Anticholinesterase poisoning
  • Irritable bowel syndrome
  • Peptic Ulcer
  • Urinary incontinence due to neurogenic bladder
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2 to 3 minutes of intravenous, intramuscular and subcutaneous administration of the dose, 5 to 20 minutes when administered through sublingual route and 20 to 30 minutes upon oral administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 4-12 hours depending upon the route of administration.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of dizziness. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to hyoscyamine or any other inactive ingredients present in the formulation.

Obstructive uropathy

This medicine is not recommended for use in patients with obstructive uropathy due to the increased risk of worsening of the patient's condition.

Myasthenia gravis

This medicine is not recommended for use in patients with myasthenia gravis due to the increased risk of worsening of the patient's condition.

Paralytic ileus

This medicine is not recommended for use in patients with paralytic ileus due to the increased risk of worsening of the patient's condition.

Closed angle glaucoma

This medicine is not recommended for use in patients with closed-angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
General warnings

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart Diseases

This medicine should be used with caution in patients with heart diseases such as coronary artery disease, heart failure, hypertension, etc due to the increased risk of worsening of the patient's condition. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperthyroidism

This medicine should be used with caution in patients with hyperthyroidism due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Oral forms: If a dose of this medicine is missed, take/administer it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one. Parenteral forms: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Oral forms: Seek emergency medical treatment or contact the doctor in case of an overdose. Parenteral forms: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of dizziness. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Phenylephrine

Metoprolol

Potassium Chloride

Acebutolol

Haloperidol

Promethazine

Chlorpheniramine

Ketoconazole

Potassium Citrate

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with liver disease due to the increased risk of adverse effects. Report any unusual symptoms to the doctor on priority. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypertension

This medicine should be used with caution in patients with hypertension due to the increased risk of worsening of the patient's condition. Regular monitoring of blood pressure, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperthyroidism

This medicine should be used with caution in patients with hypertension due to the increased risk of worsening of the patient's condition. Regular monitoring of thyroid function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney disease due to the increased risk of adverse effects. Report any unusual symptoms to the doctor on priority. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral forms: Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Parenteral forms: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by blocking the action of certain chemical and decreases the motion of intestines, stomach, and secretion of gastric fluids, etc.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Anticholinergics/antispasmodics

Schedule

Schedule H

Hyoscyamine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 4 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/hyoscyamine

Hyoscyamine - DrugBank [Internet]. Drugbank.ca. 2019 [cited 4 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB00424

[Internet]. Capellon.com. 2019 [cited 4 January 2019]. Available from:

http://www.capellon.com/PI/Symax%20SL%20500010_12-1.pdf

[Internet]. Qa.ssasoft.com. 2019 [cited 4 January 2019]. Available from:

https://qa.ssasoft.com/rxdirect/drug/attachment/PatientGuide/13299.PDF

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Information on this page was last updated on 9 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.