Hydroxyprogesterone
Description
Hydroxyprogesterone is a synthetic form of progestin and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders in women caused due to lack of hormones. It is also used to lower the risk of miscarriages or premature birth in women.
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Side effects
Major & minor side effects for Hydroxyprogesterone
- Pain,swelling, and itching at the injection site
- Lumps at the injections site
- Anxiety
- Chest pain and discomfort
- Dizziness and fainting
- Fast heartbeat
- Redness of the skin especially on the face and neck
- Increased appetite
- Nausea
Uses of Hydroxyprogesterone
What is it prescribed for?
- Premature labor
- Menstrual abnormalities
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Concerns
Commonly asked questions
- Onset of actionThe time taken for this medicine to show it's effect is subject to vary from one person to another. It also varies based on the intended use and levels of other sex hormones in the body.
- Duration of effectThe time duration for which this medicine remains effective in the body is 1-2 weeks.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use by pregnant women unless absolutely necessary and the benefits outweigh the risks associated with use. Consult your doctor before using this medicine.
- Usage while breast-feeding?This medicine is not recommended for use by breastfeeding women unless necessary. Consult your doctor before using this medicine.
Allergy
This medicine is not recommended for use if you have a known history of allergy to progesterone or any other ingredient present with it. This medicine might contain castor oil and should never be used by patients who are allergic to this component.
Abnormal vaginal bleeding
This medicine is not recommended for use if you have an abnormal bleeding episode which has not been diagnosed by a doctor.
Liver disease
This medicine is not recommended for use in patients having a liver disease or impairment of normal liver function.
Breast/Uterine cancer
This medicine is not recommended for use if you have or are suspected of having hormone related cancer i.e breast or uterine cancer.
Heart and blood vessel disorder
This medicine is not recommended for use in patients having an active or historic instance of stroke or heart attack. It should not be used by patients having an active or historic blood clotting disorder.
High blood pressure
This medicine is not recommended for use in patients having severe and uncontrolled high blood pressure.
Warnings for special population
Pregnancy
This medicine is not recommended for use by pregnant women unless absolutely necessary and the benefits outweigh the risks associated with use. Consult your doctor before using this medicine.
Breast-feeding
This medicine is not recommended for use by breastfeeding women unless necessary. Consult your doctor before using this medicine.
General warnings
Fluid retention
Use of this medicine is known to cause mild to moderate amounts of fluid retention in the body. Hence, caution is advised while administering in patients with diseases like epilepsy, asthma, migraine, heart and blood vessel disorders, kidney impairment etc.
Depression
Use of this medicine is known to cause a varying amount of depression in different individuals. It should be carefully prescribed in patients having a history of depression. Use of this medicine should be discontinued if the depressive episode becomes more frequent and severe.
Vision abnormalities
Use of this medicine can cause blurring of vision and other effects on the eye like proptosis, diplopia etc. Patients should be carefully examined to confirm if they can safely use this medicine. Any side effects like blurred vision, excessive drying of eyes should be reported to the doctor.
Blood clotting disorders
Use of this medicine can cause the formation of a blood clot in the artery or a deep vein (thromboembolism) resulting in severe to fatal adverse effects. The use of this medicine should be stopped if any such condition is confirmed.
Diabetes
Use of this medicine can affect the blood glucose levels and hence caution is advised while treating diabetic patients.
Initiation of therapy
Appropriate diagnostic tests and physical examinations should be performed to rule out other risk factors for preterm birth and miscarriages. Any hormone related cancer of the breast or uterus should also be ruled out before starting the treatment with this medicine.
Weight gain
Use of this medicine has been associated with increased fat deposit and weight gain in some patients.
Missed Dose
Contact your doctor for further instructions if you miss a scheduled dose of this medicine.
Overdose
Contact a doctor if an overdose with this medicine is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Carbamazepine
Ketoconazole
Warfarin
Cyclosporine
Insulin
Paracetamol
Disease interactions
Breast cancer
Use of this medicine is not recommended for patients having an active case of breast cancer or are suspected of having it. Report all such instance including occurrence in the past to the doctor so that an informed decision can be taken in regards to the future treatment plan.
Liver Disease
Use of this medicine is not recommended if the patient has a liver disease or the normal liver function is impaired.
Thromboembolism
Use of this medicine is not recommended in patients having a clotting disorder in which the formed clot moves from one place and lodges in another place.
Depression
This medicine should be used with caution in patients having episodes of depression or having a history of depression especially when estrogen is also administered in combination. The drug should be discontinued if the depression recurs and is serious.
Retinal thrombosis
Use of this medicine can sometimes cause a loss of vision by blocking the flow of blood from the retina to the heart. Hence caution should be exercised while using it and any abnormality in vision should be reported to the doctor.
Food interactions
Information not available.
Lab interactions
Thyroid function test
Report the use of hydroxyprogesterone to the doctor before undergoing a thyroid function test. This medicine can interfere with the test and give a false positive result.
Take Hydroxyprogesterone as instructed by the doctor. It is advised to take this medicine under medical supervision. Regular follow up and check up is advised while taking this medicine.
Miscelleneous
How it works
This medicine acts by mimicking the actions of progesterone and helps in regulation of ovulation and menstruation in women of childbearing age. It also prevents premature uterine contraction caused due to oxytocin.
Legal Status
Classification
Category
Progestins
Schedule
Schedule H
DailyMed - Hydroxyprogesterone caproate injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 April 2017]. Available from:
PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 28 April 2017]. Available from:
[Internet]. Accessdata.fda.gov. 2017 [cited 16 November 2017]. Available from:
[Internet]. Accessdata.fda.gov. 2017 [cited 16 November 2017]. Available from:
Information on this page was last updated on 16 Nov 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.