Hydrochlorothiazide

Description

Hydrochlorothiazide is a diuretic, which is used to control high blood pressure and edema. It should be used with caution in patients with severe kidney disease. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine.

Side effects

Major & minor side effects for Hydrochlorothiazide

  • Increased urination
  • Itching or rash
  • Abdominal and stomach pain
  • Dry mouth
  • Joint pain, stiffness, and swelling
  • Cramping
  • Weakness

Uses of Hydrochlorothiazide

What is it prescribed for?

  • Edema
  • Hypertension
  • Congestive Heart Failure
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed in 2 hours after oral administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 to 12 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while you are taking this medicine. The combination may increase the risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is recommended for use in pregnant women only when necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Hydrochlorothiazide or other sulfonamide-derived medicines.

Anuria

This medicine is not recommended for use in patients with a condition called anuria (a condition where the kidney is unable to produce urine).
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnant women only when necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
General warnings

Hepatic dysfunction

Hydrochlorothiazide should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority.

Volume and electrolyte depletion

Hydrochlorothiazide may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

Renal disease

Hydrochlorothiazide may cause Azotemia in patients with a known history of a severe renal disease. Close monitoring of kidney function is necessary while taking this medicine. Appropriate dose adjustments should be done based on the renal function.

Missed Dose

If a dose of Hydrochlorothiazide is missed, take the dose as soon as you remember. If it is almost the time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while you are taking this medicine. The combination may increase the risk of dizziness, fainting, and very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
Interaction with Medicine

Insulin

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Diabetes

Hydrochlorothiazide may increase the blood glucose levels in patients with diabetes. Close monitoring of blood glucose levels is necessary for such patients. Suitable dose adjustments may be required based on the clinical condition of the patient.

Hyperuricemia

Hydrochlorothiazide should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion. This may cause serious side effects. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Hydrochlorothiazide as advised by your doctor. Do not take in larger amounts than prescribed. Take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. This medicine should be used with caution due to the risk of dizziness.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Thiazide diuretics

Schedule

N/A

Hydrochlorothiazide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00999

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 21 July 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

DailyMed - HYDROCHLOROTHIAZIDE- hydrochlorothiazide tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7b38ac8a-4540-4eb2-aedd-9aa966d22190

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Information on this page was last updated on 1 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.