Human Thrombin

Description

Human Thrombin is a sterile solution containing plasma-derived human thrombin that helps in the clotting of blood and prevents bleeding. This medicine is used as an adjunct in the surgical procedures to stop bleeding where the standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical.

Side effects

Major & minor side effects for Human Thrombin

  • Difficulty in breathing
  • Slow or slurred speech
  • Skin rash
  • Weakness
  • Injection site pain
  • Changes in vision
  • Severe headache
  • Chest pain or discomfort
  • Nausea and Vomiting
  • Loss of coordination

Uses of Human Thrombin

What is it prescribed for?

  • Bleeding
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed immediately after the administration.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known history of allergy to this medicine or any other inactive ingredients present in the medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Other medicines

Human Thrombin may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Instructions for use

Human Thrombin is not intended for intravascular administration. Use this medicine in the presence of active blood flow and apply adequate quantity to cover the wound completely.

Ophthalmic procedures and Post-partum bleeding

The safety and efficacy of the use of this medicine in eye surgeries or procedures and bleeding after delivery have not been clinically established.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine converts plasma fibrinogen into fibrin which results in clot formation and stops bleeding.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Hemostatics

Schedule

Schedule H

Human Thrombin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 26 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB11571

[Internet]. Floseal.com. 2018 [cited 26 September 2018]. Available from:

http://www.floseal.com/int/pdf/FLOSEAL_VHSD_EU_IFU_0707556.pdf

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Information on this page was last updated on 5 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.