Human Rabies Immunoglobulin

Description

Human Rabies Immunoglobulin is a human-derived rabies immunoglobulin which is used to protect against rabies infection. It is administered in individuals who are suspected of exposure to rabies after contact with a rabid animal or an animal thought to be rabid. It is administered along with the first dose of rabies vaccine, within 7 days of exposure. It is not necessary to administer in individuals who had already received a rabies vaccine in the past.

Side effects

Major & minor side effects for Human Rabies Immunoglobulin

  • Difficulty in breathing
  • Dizziness
  • Cough
  • Body aches or Pain
  • Headache
  • Sneezing
  • Numbness of hands or feet
  • Unusual tiredness or weakness
  • Fever or chills
  • Skin rash

Uses of Human Rabies Immunoglobulin

What is it prescribed for?

  • Rabies Prophylaxis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed immediately after the administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Severe allergic reactions

This medicine is not recommended to be injected into a blood vessel due to the risk of severe allergic or hypersensitivity reactions, including anaphylactic shock, low blood pressure, etc. Appropriate corrective measures should be taken based on the clinical condition.

Thrombosis

This medicine may cause thrombosis (formation of a blood clot within a blood vessel) or thrombotic events in some patients. Appropriate corrective measures should be taken based on the clinical condition.

Hemolysis

This medicine may cause destruction of red blood cells in some patients. Report any unusual symptoms such as fever, chills, or dark urine to the doctor immediately. Appropriate corrective measures should be taken based on the clinical condition.

Serologic testing

This medicine may interfere with serologic testing causing a short time rise of the various passively transferred antibodies in the blood, which may give false positive results.

Transmissible infectious agents

Use of this medicine may increase the potential risk of transmission of infectious agents such as viruses since it is derived from human plasma. Therefore it is advised to screen the donor for any prior exposure to certain viruses or viral infections.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live attenuated vaccines and related products

Phenytoin

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine partially suppresses the active production of antibodies and prevents rabies virus from spreading across the body.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Immune globulins

Schedule

Schedule G

[Internet]. Medicines.org.uk. 2018 [cited 31 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.5543.pdf

Human Rabies Immunoglobulin - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 3 June 2019]. Available from:

https://www.medicines.org.uk/emc/product/5543

Human rabies virus immune globulin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 31 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB11603

DailyMed - Kedrab- human rabies virus immune globulin injection, solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 3 June 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=53f2a23b-c479-4c24-8cab-ee7a33a2633e

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Information on this page was last updated on 3 Jun 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.