Hibor 5000 IU Injection

Manufactured byElder Pharmaceuticals Ltd.
ContainsBemiparin
Description

Hibor 5000 IU Injection is an anticoagulant used to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain medical procedures.

Substitutes

List of substitutes for Hibor 5000 IU Injection

Side effects

Major & minor side effects for Hibor 5000 IU Injection

  • Injection site redness, bruising, or sores
  • Unusual bleeding or bruising
  • Bloody or coffee colored vomit
  • Black or tarry stools
  • Excessive menstrual bleeding
  • Dizziness and lightheadedness
  • Swelling of eyelids, face, lips, tongue
  • Difficulty in breathing
  • Difficulty in swallowing
  • Fragile or brittle bones
  • Muscle pain and weakness
  • Burning or tingling sensation of skin

Uses of Hibor 5000 IU Injection

What is it prescribed for?

  • Prophylaxis of venous thromboembolism during surgical procedures
  • Venous thromboembolic events
  • Prophylaxis of clotting during hemodialysis sessions
  • Deep Vein Thrombosis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-2 hours of administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 10-12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to bemiparin or any other inactive ingredient present along with it. Use of this medicine is also not recommended in patients having a known allergy to heparin or pork products.

Thrombocytopenia

This medicine is not recommended for use in patients with an abnormally low platelet count due to the increased risk of excessive bleeding.

Active major bleeding

This medicine is not recommended for use in patients with a known heavy active bleeding due to the increased risk of worsening of the patient's condition.

Bacterial endocarditis

This medicine is not recommended for use in patients having a swelling of the heart walls or valves due to bacterial infections (bacterial endocarditis).

Epidural/spinal anesthesia

This medicine is not recommended for use for the prevention of venous thromboembolic events in patients receiving epidural/spinal anesthesia due to the increased risk of a hematoma.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established. Your doctor may decide the best course of treatment after assessing your condition.
General warnings

Hemorrhage and risk factors

Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.

Thrombocytopenia

Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver/kidney disease

This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.

Epidural/spinal/regional anesthesia

This medicine should not be used in patients receiving regional, epidural, or spinal anesthesia due to the increased risk of excessive bleeding and formation of hematoma.

Interchangeability with other heparins

This medicine should not be used interchangeably with other low molecular weight heparins.

Intramuscular route

This medicine should not be administered via the intramuscular route.

Use in children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Missed Dose

This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.

Overdose

Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clopidogrel

Escitalopram

Warfarin

Aspirin

Heparin

Diclofenac

Streptokinase

Dextran

Disease interactions

Hemophilia

This medicine should be administered with extreme caution in patients suffering from hemophilia or other bleeding disorders due to the increased risk of excessive bleeding.

Liver Disease

This medicine should be administered with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function may be necessary based on the clinical condition.

Peptic ulcer disease

This medicine should be administered with extreme caution in patients with peptic ulcer disease due to the increased risk of excessive bleeding.

Pancreatitis

This medicine should be used with caution in patients suffering from pancreatitis or impaired pancreatic function due to the increased risk of worsening of the patient's condition.

Kidney disease

This medicine should be administered with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments should be done based on the clinical condition.

Uncontrolled hypertension

This medicine is not recommended for use in patients having an uncontrolled high blood pressure. Therapy with this medicine should be started only after the hypertension is under control.
Food interactions
This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
Lab interactions
Information not available.
Administer Hibor 5000 IU Injection exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Heparins

Schedule

Schedule H

[Internet]. 2017 [cited 31 August 2017]. Available from:

http://www.cimerman.com.br/artigos/Pneumologia/51-tvp%20e%20bumeparina.pdf

Bemiparin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 31 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB09258

[Internet]. Medicines.org.uk. 2017 [cited 31 August 2017]. Available from:

http://www.medicines.org.uk/emc/PIL.21559.latest.pdf?documentid=21559

Review of bemiparin sodium--a new second-generation low molecular weight heparin and its applications in venous thromboembolism. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 31 August 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/12943485

[Internet]. 2017 [cited 4 September 2017]. Available from:

http://www.meppo.com/pdf/drugs/875-HIBOR-1444208315.pdf
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