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Grenil Suspension

Manufactured byKARNATAKA ANTIBIOTICS & PHARMACEUTICALS LTD
ContainsDomperidone (5 mg/5 ml) + Paracetamol (250 mg/5 ml)
Description

Grenil Suspension is a combination medicine that may be used to treat the symptoms associated with a migraine headache, a moderate to severe type of a headache with throbbing pain on one side of the head, often accompanied by nausea and vomiting.

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Side effects

Major & minor side effects for Grenil Suspension

  • Bloody and cloudy urine
  • Tiredness and weakness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficulty in breathing
  • Skin rash
  • Dry mouth
  • Indigestion
  • Diarrhea

Uses of Grenil Suspension

What is it prescribed for?

  • Migraine
  • Nausea, Vomiting, Pain, and Fever
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as dizziness, drowsiness, difficulty concentrating, gastrointestinal bleeding, weakness, fatigue, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to domperidone, paracetamol, or any other inactive ingredients present in the formulation.

Analgesic Nephropathy (Kidney Disease)

This medicine is not recommended for use in patients suffering from kidney diseases associated with the excessive use of painkillers due to the increased risk of worsening of the patient's condition.

Severe liver impairment

This medicine is not recommended for use in patients suffering from a severe liver function impairment due to the increased risk of worsening of the patient's condition.

Prolactin-releasing pituitary tumour (Prolactinoma)

This medicine is not recommended for use in patients suffering from a prolactinoma, a benign noncancerous tumor of the pituitary gland that produces a hormone called prolactin, due to the increased risk of worsening of the patient's condition.

Heart diseases

This medicine is not recommended for use in patients suffering from active heart diseases such as congestive heart failure due to the increased risk of worsening of the patient's condition.

Gastrointestinal hemorrhage

This medicine is not recommended for use in patients suffering from a gastrointestinal hemorrhage due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Chronic Malnutrition

This medicine should be used with extreme caution in patients suffering from malnourishment due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Electrolyte imbalance

This medicine should be used with extreme caution in patients with acute or long-term electrolyte imbalance due to the increased risk of worsening of the patient's condition. Regular monitoring of electrolyte levels is recommended for such patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Lactose intolerance

Some formulations of this medicine may contain lactose and may be unsuitable for patients suffering from lactose intolerance, galactosemia, or glucose/galactose malabsorption. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Missed Dose

Take/Administer the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as dizziness, drowsiness, difficulty concentrating, gastrointestinal bleeding, weakness, fatigue, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Carbamazepine

Cisapride

Erythromycin

Ketoconazole

Phenytoin

Tramadol

Sodium Nitrite

Leflunomide

Prilocaine

Bromocriptine

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of the kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with liver diseases due to the increased risk of serious adverse effects and worsening of the patient's condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Intestinal Disorders

This medicine should be used with extreme caution in patients suffering from serious intestinal problems such as internal bleeding, an obstruction or perforation of the stomach and intestine, etc. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Alcoholism

This medicine should be used with extreme caution in patients with chronic alcohol use due to the increased risk of serious liver injuries. Close monitoring of liver function is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

You may get a false-positive result for this test while taking this medicine. It is advised that you inform the doctor and lab technician about all your current medicines including any herbs and supplements before undergoing any lab tests.
Take/Administer this medicine exactly as advised by your doctor. Do not take in larger or smaller quantities than recommended. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Domperidone works by blocking certain chemicals in the brain and the intestine; this helps to control nausea and vomiting. Paracetamol increases the pain threshold. It also blocks the release of certain chemicals which are responsible for causing pain and swelling. Their combination is thus better effective in the treatment of a migraine headache.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antimigraine agents, Antiemetics, Miscellaneous analgesics

Schedule

Schedule H

[Internet]. 2017 [cited 8 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/23098

Domperidone | C22H24ClN5O2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 8 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3151#section=Top

Acetaminophen | C8H9NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 22 February 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/1983#section=Top

Acetaminophen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 22 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a681004.html

[Internet]. CiplaMed. 2018 [cited 22 August 2018]. Available from:

https://ciplamed.com/content/domcet-tablet-suspension
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Information on this page was last updated on 15 Jul 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.