Gp Met (500/5 mg) Tablet

Manufactured byApostle Remedies
ContainsMetformin (500 mg) + Glipizide (5 mg)
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Description

Gp Met (500/5 mg) Tablet is a combination medicine used for the treatment of type 2 diabetes mellitus. This medicine is not recommended for use in patients below 18 years of age.

Substitutes

List of substitutes for Gp Met (500/5 mg) Tablet

Side effects

Major & minor side effects for Gp Met (500/5 mg) Tablet

  • Anxiety
  • Blurred vision
  • Chills
  • Confusion
  • Depression
  • Fast heartbeat
  • Fever
  • Headache
  • Increased hunger
  • Nausea
  • Nervousness
  • Sore throat
  • Unusual tiredness and weakness

Uses of Gp Met (500/5 mg) Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 minutes of oral administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 12-24 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to glipizide, any other sulfonylureas, metformin, or any other biguanides.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type I diabetes mellitus.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypoglycemia

This medicine may cause hypoglycemia in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver disease

This medicine should be used with caution in patients with a known history of liver disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients with a known history of kidney disease due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of heart function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hemolytic anemia

This medicine may cause hemolytic anemia in some patients. This risk is especially higher in patients suffering from a G6PD deficiency. Replacement with a suitable alternative may be required in such patients based on the clinical condition.

Alcohol use

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.

Photo-sensitivity

This medicine may cause allergic skin reactions on exposure to sunlight in some patients. Patients are advised to use sunscreen and wear protective clothing to avoid these reactions. Replacement with a suitable alternative may be required in the reactions are severe.

Change of medications

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Use in children

This medicine is not recommended for use in children and adolescents.

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose. Symptoms of an overdose may include confusion, weakness, nausea, vomiting, tremors, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Amlodipine

Atenolol

Estradiol

Gatifloxacin

Miconazole

Iodinated Contrast Media

Aloe Vera

Selegiline

Ibuprofen

Disease interactions

Heart Disease

This medicine should be administered with extreme caution in patients suffering from a disease of the heart or blood vessels due to the increased risk of serious adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Diabetic Ketoacidosis

This medicine is not recommended for use in patients suffering from diabetic ketoacidosis since the risk of adverse effects is significantly high. Replacement with a suitable alternative should be considered under your doctor's supervision.

Kidney Disease

This medicine should be administered with extreme caution in patients with a known history of renal impairment due to the increased risk of serious adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine should be used with extreme caution in patients predisposed to hypoglycemic episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the blood glucose levels.

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients suffering from hemolytic anemia or G6PD deficiency since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Lactic Acidosis

This medicine may cause lactic acidosis in some patients. This risk is especially higher in patients with kidney diseases, heart diseases, or septicemia. Close monitoring of blood glucose levels, kidney function, heart function, and liver function may be required for such patients based on the clinical condition. Report any symptoms such as fatigue, breathing difficulty, increased sleep, nausea, vomiting, diarrhea, irregular heartbeat, etc. to the doctor immediately. Appropriate corrective measures and discontinuation of therapy may be required in some cases based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as prescribed by the doctor. It is advised to take this medicine just before meals or with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Glipizide works by increasing the release of insulin from the pancreas. The combination is thus better effective than monotherapy in lowering the blood glucose levels.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

[Internet]. 2017 [cited 21 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021460s010lbl.pdf

DailyMed - Metformin hcl tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d98aea3-35ba-447a-b88f-a5a20b612b2f

[Internet]. 2017 [cited 29 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021460s007lbl.pdf
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