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Glycozide-MP Tablet
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Glycozide-MP Tablet

Manufactured byEast West Pharma
ContainsMetformin (500 mg) + Gliclazide (80 mg) + Pioglitazone (15 mg)
Description
Glycozide-MP Tablet is a combination of Metformin, Gliclazide, and Pioglitazone. It is an anti-diabetic medicine used as a third-line medicine for the treatment of type II diabetes in adults. It works by increasing insulin release and improving your body's response to insulin (a hormone that enables your body to use sugar). However, due to serious side effects, this combination is banned in India. It also prevents the breakdown of carbohydrates to glucose (sugar) and thereby lowers your blood sugar levels.  Glycozide-MP Tablet may result in low blood sugar levels and you may feel hungry, irritable, confused, or anxious. It is always recommended to eat a fast-acting source of sugar (fruit juice, candy, raisins, etc.) to quickly treat these symptoms. Other common side effects include headaches, dizziness, nausea, diarrhoea, etc. Consult your doctor if these symptoms persist or if they become severe. Glycozide-MP Tablet should be taken exactly as advised by your doctor. Take it at the same time every day to maintain a constant level of this medicine in your body. Do not skip a dose or discontinue the treatment as it may cause an increase in your blood sugar levels.  Glycozide-MP Tablet is not recommended if you are allergic to it. Inform your doctor if you have kidney, liver, or heart problems before beginning the treatment. This medicine is not recommended for use in children and adolescents below 18 years of age. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Glycozide-MP Tablet

  • Dizziness
  • Nausea or vomiting
  • Diarrhoea
  • Confusion
  • Weakness
  • Changes in vision
  • Decreased heartbeat
  • Abdominal pain
  • Constipation
  • Skin rash
  • Sweating

Uses of Glycozide-MP Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Glycozide-MP Tablet can be observed within 1 to 3 hours of taking it.
  • How long do the effects of this medicine last?
    The effect of Glycozide-MP Tablet lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Glycozide-MP Tablet as it may increase the risk of lactic acidosis (increased blood lactic acid levels). It may also affect the ability of this medicine to control your blood sugar levels.
  • Is this a habit forming medicine?
    No habit-forming tendencies have been reported with Glycozide-MP Tablet.
  • Can this medicine be taken during pregnancy?
    Due to a lack of sufficient safety and efficacy data, Glycozide-MP Tablet is not recommended for use in pregnancy. If you are pregnant or planning a pregnancy, consult your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Glycozide-MP Tablet may passes into breastmilk. This medicine is not recommended while breastfeeding due to the increased risk of hypoglycaemia (low blood sugar levels) in your infant. If you are breastfeeding, consult your doctor before taking this medicine.

Allergy

Avoid taking Glycozide-MP Tablet if you are allergic to it. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Severe Kidney disease

Kidney impairment is the loss of kidney function. Glycozide-MP Tablet is not recommended if you have severe kidney problems as it may cause complications such as lactic acidosis (acid buildup in the blood).

Metabolic Acidosis

Metabolic acidosis is characterized by high levels of acids in your blood. The symptoms include thirst, frequent urination, vomiting, abdominal pain, weakness, muscle cramps, etc. Glycozide-MP Tablet is not recommended if you have metabolic acidosis as this medicine may worsen your condition.

Severe liver disease

Liver impairment is the loss of liver function. Because of the increased risk of severe side effects, Glycozide-MP Tablet is not recommended if you have liver problems.

Type 1 Diabetes mellitus

Type 1 diabetes, also known as insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin. Symptoms include increased thirst, frequent urination, hunger, fatigue, and blurred vision. Glycozide-MP Tablet is not recommended if you have type 1 diabetes mellitus.
Warnings for special population

Pregnancy

Due to a lack of sufficient safety and efficacy data, Glycozide-MP Tablet is not recommended for use in pregnancy. If you are pregnant or planning a pregnancy, consult your doctor before taking this medicine.

Breast-feeding

Glycozide-MP Tablet may passes into breastmilk. This medicine is not recommended while breastfeeding due to the increased risk of hypoglycaemia (low blood sugar levels) in your infant. If you are breastfeeding, consult your doctor before taking this medicine.
General warnings

Hypoglycemia

Glycozide-MP Tablet may cause hypoglycaemia. Regular monitoring of your blood sugar levels is recommended. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels when necessary.

Surgery

Glycozide-MP Tablet is not recommended to be used during surgery due to the increased risk of lactic acidosis (high levels of lactic acid in the blood). If you are taking this medicine, inform your doctor before undergoing any surgery. Your doctor may suggest you discontinue the treatment before surgery.

Ovulation problems

Glycozide-MP Tablet should be used with caution in premenopausal patients due to the increased chances of ovulation. Adequate contraceptive measures are recommended to avoid an unplanned pregnancy.

Use in children

Glycozide-MP Tablet is not recommended for use in children and adolescents below 18 years of age due to a lack of safety and efficacy data.

Driving or operating machines

Glycozide-MP Tablet may cause low blood sugar levels and dizziness which may affect your mental alertness. Avoid driving vehicles or operating machines if you experience these symptoms after taking this medicine.

Missed Dose

Do not skip any dose of Glycozide-MP Tablet. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double the dose to compensate for a missed one.

Overdose

Do not take excess dose than prescribed by your doctor. Contact your doctor in case of an overdose with Glycozide-MP Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Glycozide-MP Tablet as it may increase the risk of lactic acidosis (increased blood lactic acid levels). It may also affect the ability of this medicine to control your blood sugar levels.
Interaction with Medicine

Estradiol

Corticosteroids

Azole antifungal agents

Iodinated Contrast Media

ACE inhibitors

Disease interactions

Hemolytic Anemia/G6PD Deficiency

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic condition in which your red blood cells break down when exposed to certain medicines, infections, or stress. Glycozide-MP Tablet is not advised if you have this condition because it can lead to haemolytic anaemia (low red blood cell count).

Cardiovascular disease

Glycozide-MP Tablet should be used with caution if you have any pre-existing heart problems due to the increased risk of worsening your condition. Close monitoring of your heart function and vital signs is recommended.

Bladder cancer

Glycozide-MP Tablet is not recommended for use if you have active bladder cancer as this may increase the risk of serious adverse effects. Replacement with a suitable alternative should be considered under your doctor's supervision.

Vitamin B12 deficiency

Glycozide-MP Tablet should be used with caution if you have vitamin B12 deficiency. This medicine interferes with the absorption of Vitamin B12 in your body. Consult your doctor if you are taking these medications together.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Glycozide-MP Tablet with food or as prescribed by your doctor. Avoid taking more than the prescribed dose as it may increase the risk of side effects.  Avoid the discontinuation of Glycozide-MP Tablet without consulting your doctor. Consult the doctor if you experience any undesirable side effects. Regular follow-up visits with your doctor are recommended to evaluate your condition. Your doctor may suggest regular monitoring of your blood sugar levels to check that your diabetes is under control. Maintain a proper diet and do regular exercise to get the maximum benefits from the treatment. You should always carry a sugary treat with you to counteract the unexpected lowering of blood sugar levels. Keep away from the reach of children and pets. Do not use it after the expiry date. Ensure that the unused medicine is disposed of properly.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Glycozide-MP Tablet is a combination medicine of Metformin, Gliclazide, and Pioglitazone. Metformin works by improving the body’s response to insulin and decreasing glucose (sugar) production in the liver. This helps in lowering the increased blood sugar levels. It works by increasing the release of insulin from your pancreas (a part of your digestive system that produces insulin and other vital enzymes). Thus, it lowers your blood sugar levels. Pioglitazone decreases insulin resistance without causing any strain on the pancreas and reduces the production of glucose from the liver.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2021. DailyMed - PIOGLITAZONE tablet. [online] Available at: < [Accessed 3 December 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f2d7000-37ca-4e09-98ec-07d1c0354cb3>

Drugs, H., 2021. Pioglitazone: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 3 December 2021].

https://medlineplus.gov/druginfo/meds/a699016.html>

Dailymed.nlm.nih.gov. 2021. DailyMed - METFORMIN HCL tablet. [online] Available at: < [Accessed 3 December 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d98aea3-35ba-447a-b88f-a5a20b612b2f>

Medicines.org.uk. 2021. [online] Available at: < [Accessed 3 December 2021].

https://www.medicines.org.uk/emc/PIL.26348.latest.pdf>
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Information on this page was last updated on 29 Dec 2021

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