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Gilran M 40 Tablet

Manufactured byRanmarc Labs
ContainsMetformin (500 mg) + Gliclazide (40 mg)
Description

Gilran M 40 Tablet is a combination medicine which may be used to control blood sugar level in patients with type 2 diabetes. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Gilran M 40 Tablet

  • Dizziness
  • Nausea or vomiting
  • Constipation
  • Sweating
  • Changes in vision
  • Decreased heartbeat
  • Skin rash
  • Flushing or redness of skin
  • Diarrhea
  • Metallic taste
  • Low blood sugar levels (hypoglycemia)
  • Weakness
  • Chest discomfort
  • Headache

Uses of Gilran M 40 Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 to 3 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to gliclazide, metformin, other sulfonylureas, other biguanides, or any other inactive ingredients present in the formulation.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.

Severe Hepatic impairment

This medicine is not recommended for use in patients with a known history of severe liver impairment due to the increased risk of serious adverse effects.

Diabetic pre-coma and coma

This medicine is not recommended for use in patients with a diabetic pre-coma or coma since it may worsen the patient's condition.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type I diabetes mellitus since it is not effective in treating such patients.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypoglycemia

This medicine should be administered with caution in patients prone to having hypoglycemic episodes due to the increased risk of serious adverse effects. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with extreme caution in patients with an impaired kidney function due to an increase in the risk of kidney injuries and serious adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with an impaired liver function due to an increase in the risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Alcohol use

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Lactic Acidosis

Use of this medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required in some cases.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Amlodipine

Estradiol

Gatifloxacin

Phenytoin

Azole antifungal agents

Rifampicin

Iodinated Contrast Media

Aloe Vera

Phenylbutazone

Chlorpromazine

Glucocorticoids

Disease interactions

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients with Hemolytic Anemia or G6PD deficiency due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Heart Disease

This medicine should be administered with extreme caution in patients suffering from a disease of the heart or blood vessels due to the increased risk of serious adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as prescribed by the doctor. It is advised to take this medicine just before meals or with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor. This medicine will show better results if you maintain a strict exercise and diet regimen. Consult the doctor if you experience any undesirable side effects.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Gliclazide works by increasing the release of insulin from the pancreas. The combination is thus better effective than monotherapy in lowering the blood glucose levels.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations, Oral Biguanide, Sulfonylureas

Schedule

Schedule H

[Internet]. 2017 [cited 22 September 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/4638

Metformin | C4H11N5 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4091#section=Top

Gliclazide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 March 2017]. Available from:

https://www.drugbank.ca/drugs/DB01120

DailyMed - Metformin hcl tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d98aea3-35ba-447a-b88f-a5a20b612b2f
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Information on this page was last updated on 7 Jun 2019

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