Gentamicin

Description

Gentamicin is bactericidal antibiotic which is used to treat a variety of infections caused by the bacteria in the brain, bone, and urinary tract. This medicine may increase the risk of kidney injury or hearing problem. It is avoided in the patients with the known allergy to aminoglycosides.

Side effects

Major & minor side effects for Gentamicin

  • Abdominal pain
  • Agitation
  • Blurred vision
  • Changes in urine frequency
  • Hearing loss
  • Dizziness when getting up suddenly from a sitting position
  • Dry mouth
  • Fast heartbeat
  • Itching or rash
  • Increased salivation
  • Depression

Uses of Gentamicin

What is it prescribed for?

  • Bacteremia
  • Intraabdominal Infection
  • Bacterial Meningitis
  • Osteomyelitis
  • Skin and Soft tissue infections
  • Pyelonephriits
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 30 to 90 minutes for an intramuscular injection and 30 minutes after an intravenous injection.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 to 8 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women.
  • Usage while breast-feeding?
    Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.

Allergy

Avoid if you have a known allergy to Gentamicin or any other aminoglycosides.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.
General warnings

Hearing loss

Gentamicin is not recommended in the patients with existing kidney injury or hearing problem it may increase the risk of deafness.

Impaired kidney function

Gentamicin may increase the risk of kidney injury especially when high doses are used or when the treatment prolongs for a longer time. Suitable dose adjustments are to be made based on the CrCl.

Neuromuscular disorders

Gentamicin is not recommended in the patients with existing neuromuscular diseases like Parkinson's disease.

Drug-resistance

Usage of {Gentamicin}} without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Furosemide

Nonsteroidal anti-inflammatory drugs

Cephalosporins

Disease interactions

Dehydration

Consume an adequate amount of water to prevent kidney injury and hearing problem. Fluid status should be monitored closely in the patients with severe diarrhea and vomiting. Frequent monitoring of kidney function tests is necessary. Dose adjustments are to be made based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
You should carefully follow all instructions on the label. The duration and amount of medicine consumed should be as prescribed by the doctor. It can be taken with food or after food. An adequate amount of water should be consumed to minimize the irritation caused in the stomach.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by inhibiting the protein synthesis which is essential for the bacteria to grow.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Aminoglycosides

Schedule

Schedule H

[Internet]. 2017 [cited 5 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/32933

Gentamicin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 5 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682275.html

DailyMed - Gentamicin sulfate injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 5 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84f5c763-1cd3-4d85-9afb-934db8666fbf#dd8e2f25-906a-42b0-b8ce-684796a010fb

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 5 April 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 5 April 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~61VZ65:1

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.