Fosfomycin

Description

The primary ingredient of Fosfomycin is available as oral powder and injection. The oral powder form of this medicine is used for the treatment of bacterial infections of the urinary tract in women. The parenteral form of this medicine is used for the treatment of infections of the bone, respiratory tract, brain, blood, urinary tract, etc. caused by susceptible bacteria.

Side effects

Major & minor side effects for Fosfomycin

  • Diarrhea
  • Nausea and vomiting
  • Headache
  • Dizziness
  • Unusual tiredness and weakness
  • Indigestion
  • Visual disturbances
  • Skin rash
  • Increased heartrate
  • Difficulty in breathing

Uses of Fosfomycin

What is it prescribed for?

  • Acute Cystitis
  • Acute Osteomyelitis
  • Complicated Urinary Tract Infection
  • Nosocomial Lower Respiratory Tract Infections
  • Bacterial Meningitis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to fosfomycin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
General warnings

Diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Liver impairment

This medicine should be used with extreme caution in patients with liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other medicines

Fosfomycin may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Oral form: The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose. Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Oral form: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live cholera vaccine

Balsalazide

Disease interactions

Colitis

This medicine should be used with caution in patients with gastrointestinal diseases, especially colitis due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral form: Take this medicine exactly as instructed by the doctor. The powder should be mixed with water. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe adverse effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor Injection: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by inhibiting the growth of the bacteria by interfering with the bacterial cell wall synthesis
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous antibiotics, Urinary anti-infectives

Schedule

Schedule H

Fosfomycin - DrugBank [Internet]. Drugbank.ca. 2019 [cited 5 April 2019]. Available from:

https://www.drugbank.ca/drugs/DB00828

[Internet]. Paladin-labs.com. 2018 [cited 19 September 2018]. Available from:

http://www.paladin-labs.com/our_products/Monurol-Sachet-PM-En.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 19 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050717s005lbl.pdf

Fosfomycin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 19 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a697008.html

Fosirol Powder [Internet]. CiplaMed. 2019 [cited 5 April 2019]. Available from:

https://ciplamed.com/content/fosirol-powder

Crifos 4 GM Injection [Internet]. CiplaMed. 2019 [cited 5 April 2019]. Available from:

https://ciplamed.com/content/crifos-4-gm-injection

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Information on this page was last updated on 5 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.