Fosaprepitant

Description

Fosaprepitant is an antiemetic medicine which is used along with other medications to prevent acute and delayed nausea and vomiting associated with cancer chemotherapy in adults and children above six months of age. It works by blocking the action of a natural substance that causes nausea and vomiting.

Side effects

Major & minor side effects for Fosaprepitant

  • Loss of appetite
  • Tiredness
  • Headache
  • Dry mouth
  • Difficulty in breathing
  • Dizziness
  • Increased heartrate
  • Difficult or painful urination
  • Pale skin
  • Chest tightness

Uses of Fosaprepitant

What is it prescribed for?

  • Chemotherapy induced nausea and vomiting
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to fosaprepitant or any other inactive ingredients present along with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

QT Prolongation

This medicine may cause prolongation of the QT interval and hence should be used with extreme caution in patients with QT prolongation since it may worsen the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Since this medicine is usually administered in the clinical/hospital setting, the likelihood of missing a dose is very low.

Overdose

Since this medicine is usually administered in the clinical/hospital setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Deflazacort

Pimozide

Tacrolimus

Warfarin

Atorvastatin

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the action of certain natural substances that can trigger nausea and vomiting.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

NK1 receptor antagonists

Schedule

Schedule H

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 3 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Fosaprepitant#section=Top

[Internet]. Accessdata.fda.gov. 2019 [cited 3 January 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022023s017lbl.pdf

[Internet]. Drugbank.ca. 2019 [cited 3 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB06717

[Internet]. Medicines.org.uk. 2019 [cited 3 January 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.5947.pdf

DailyMed - Emend- fosaprepitant dimeglumine injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 15 May 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d66803a-6811-4c29-9c57-e16acfa87f21

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Information on this page was last updated on 15 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.