Fondaparinux

Description

Fondaparinux is used to prevent the formation and growth of blood clots that may potentially form during certain surgical procedures and in patients with certain specific medical conditions like acute coronary syndrome (sudden or reduced blood flow to the heart) with or without ST-segment elevation or unstable angina. It also helps in preventing the formation of blood clots in catheters that are placed in veins for a prolonged period of time. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Fondaparinux

  • Pale skin
  • Trouble breathing
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Fever
  • Nausea or Vomiting
  • Bleeding gums
  • Dizziness
  • Sore throat
  • Dry mouth

Uses of Fondaparinux

What is it prescribed for?

  • Deep Vein Thrombosis Prophylaxis and Treatment after surgery
  • Deep Vein Thrombosis
  • Pulmonary Embolism
  • Acute Coronary Syndrome
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 2-3 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to fondaparinux or any other inactive ingredients present along with it.

Active major bleeding

This medicine is not recommended for use in patients having major active bleeding due to the increased risk of worsening of the patient's condition.

Bacterial endocarditis

This medicine is not recommended for use in patients with bacterial endocarditis due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (creatinine clearance < 30 ml/min) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Subcutaneous use only

This medicine is intended for subcutaneous use only. Do not administer intramuscularly.

Bleeding

This medicine is known to cause severe bleeding. It is not recommended for patients with conditions like gastrointestinal bleeding, head injury, and patients who are about to undergo surgery. Any symptoms of blood in the stools, vomiting blood, or blood in the urine should be reported to the doctor on priority. Close monitoring of prothrombin time is necessary while receiving this medicine.

Other medicines

Concomitant administration of this medicine and other anticoagulants may enhance the risk of bleeding. These agents include desirudin, fibrinolytic agents, GP IIb/IIIa receptor antagonists, heparin, heparinoids, or Low Molecular Weight Heparin (LMWH). Other antiplatelet medicinal products (acetylsalicylic acid, dipyridamole, sulfinpyrazone, ticlopidine or clopidogrel), and NSAIDs should be used with caution. Close monitoring is necessary if coadministered.

Spinal or epidural Anesthesia and Post-operative Indwelling Epidural catheter use

Use of this medicine with spinal or epidural anesthesia or spinal puncture may result in spinal or epidural hematomas, which may result in long-term or permanent paralysis. The risk of these events may be higher with post-operative use of indwelling epidural catheters or concomitant use of other drugs affecting hemostasis such as NSAIDs. Monitor patients undergoing these procedures for signs and symptoms of neurologic impairment such as midline back pain, sensory and motor deficits (numbness, tingling, or weakness in lower limbs), and bowel or bladder dysfunction. Consider the potential risks and benefits before neuraxial intervention in patients anticoagulated or who may be anticoagulated for thromboprophylaxis.

Low body weight

This medicine is not recommended for Deep vein thrombosis (DVT)- prophylaxis if the patients weigh below 50 kg due to the increased risk of bleeding.

Platelet Count

This medicine should be used with caution since it may deplete the platelet count and increase the risk of thrombocytopenia. Regular monitoring of the platelet count is necessary while receiving this medicine. It is advised to discontinue the therapy with this medicine if the platelet count falls below 100,000/mm3.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and missed a scheduled dose, then call your doctor immediately for further instructions.

Overdose

Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms of an overdose may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Enoxaparin

NSAIDs

Alteplase

Clopidogrel

Warfarin

Disease interactions

Bleeding

This medicine is not recommended for use in patients with a history of bleeding disorders or an active bleeding disorder (inability of the blood to clot normally) due to an increase in the risk of further bleeding. An alternative treatment option should be considered based on the clinical condition.

Liver Disease

This medicine is not recommended for use in patients with a liver injury/disease due to an increase in the risk of bleeding. Close monitoring of liver function and symptoms like blood in the urine and stools, dizziness, unusual bleeding, etc. are necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with mild to moderate kidney disease and not recommended in severe kidney disease condition due to the increased risk of worsening of the patient's condition. Regular monitoring of the kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer this medicine exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by blocking certain substances called clotting factors that help in the clotting of blood.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Anticoagulants, Factor Xa inhibitors

Schedule

Schedule H

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 19 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a27f341-f612-de72-8c1f-3fd977905de0

[Internet]. Medicines.org.uk. 2018 [cited 19 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/3359/smpc#

[Internet]. Drugbank.ca. 2018 [cited 19 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00569

[Internet]. Ebs.tga.gov.au. 2018 [cited 19 September 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2014-PI-02298-1&d=201809191016933

[Internet]. India-pharma.gsk.com. 2019 [cited 8 January 2019]. Available from:

https://india-pharma.gsk.com/media/701015/arixtra.pdf

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Information on this page was last updated on 8 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.