Flurbiprofen

Description

The primary ingredient of Flurbiprofen is available as ophthalmic and oral forms. The ophthalmic form of this medicine is used to treat the postoperative inflammatory conditions and for the inhibition of the intraoperative miosis (constriction of the pupil during the surgical procedure). The oral form of this medicine is used to relieve pain and swelling in conditions such as osteoarthritis, rheumatoid arthritis, etc. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Flurbiprofen

  • Abdominal pain
  • Constipation
  • Rash
  • Difficulty or painful urination
  • Nausea
  • Bleeding gums
  • Eye irritation
  • Eye pain
  • Burning and stinging of eye
  • Increased sensitivity of the eyes to light
  • A reddish tinged eye

Uses of Flurbiprofen

What is it prescribed for?

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Intraoperative Miosis
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Concerns

Commonly asked questions

  • Onset of action
    Ophthalmic form: The amount of time required for this medicine to show its action is not clinically established. Oral form: The effect of this medicine can be observed within 1 to 2 hours of administration of the dose.
  • Duration of effect
    Ophthalmic form: The amount of time for which this medicine remains active in the body is not clinically established. Oral form: The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to Flurbiprofen, any other NSAIDs, or any other inactive ingredients present along with it.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for use in patients planning to undergo a coronary artery bypass surgery or patients with a recent heart surgery due to the increased risk of severe adverse reactions.

NSAID-induced asthma

This medicine is not recommended for use in patients with a history of non-steroidal anti-inflammatory drug (NSAID) induced or aspirin-induced asthma due to the increased risk of a recurrent asthma attack.

Severe heart failure

This medicine is not recommended for use in patients with severe heart failure due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of worsening of the patient's condition.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using/taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Heart disease

The oral form of this medicine should be used with caution in patients with heart diseases due to the increased risk of adverse effects on the heart, especially after prolonged use. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney impairment

The oral form of this medicine should be used with caution in patients with mild to moderate kidney impairment due to the increased risk of adverse effects. You may require a dose adjustment and more frequent monitoring of the kidney function tests is necessary while receiving this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

The oral form of this medicine should be used with caution in patients with mild to moderate liver impairment due to the increased risk of adverse effects. You may require a dose adjustment and more frequent monitoring of the liver function is necessary while receiving this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Increased bleeding time

This medicine should be used with caution in patients with a known history of bleeding disorders due to the increased risk of excessive bleeding. Report any unusual symptoms to the doctor immediately. Close monitoring of bleeding time, appropriate corrective measures, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Herpes simplex keratitis

The ophthalmic form of this medicine should be used with caution in patients with herpes simplex keratitis due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate corrective measures, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Corneal reactions

Prolonged use of an ophthalmic form of this medicine may result in keratitis, epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration, or corneal perforation in some patients. Appropriate corrective measures or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Contact lens

Your doctor may ask you to stop the usage of contact lenses for up to a few days prior to the surgery and for up to a few days to a few months post-surgery depending on the type of eye surgery performed. If you are able to use contact lenses post-surgery, they should be removed prior to the administration of the eye drops. You are advised to wait for at least 10 to 15 minutes post administration of the eye drops before re-inserting the lenses.

Contamination

Do not touch the tip of the dropper to any surface since this may lead to contamination by bacteria. Patients are advised to take all hygienic precautions to ensure that the medicine is not contaminated.

Skin rash

The oral form of this medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Oral form: Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose. Ophthalmic form: Administer the missed dose as soon as you remember. It is advisable to skip the missed dose if it is almost time for your next scheduled dose. Do not instill a double dose to make up for the missed one. If it is used during a surgical procedure, the likelihood of missing a dose is very less.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Warfarin

Prednisolone Ophthalmic

Rimexolone Ophthalmic

Disease interactions

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-induced asthma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be done under your doctor's supervision.

Fluid retention

The oral form of this medicine may cause fluid retention in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Gastro-Intestinal toxicity

The oral form of this medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Anemia

The oral form of this medicine should be used with caution in patients with or predisposed to anemia due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral form: Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. Ophthalmic form: Use this medicine exactly as prescribed. Do not administer in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. If this medicine is used during surgeries, it is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by blocking the formation of certain chemical substances in the body which are responsible for causing pain and swelling.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Nonsteroidal anti-inflammatory agents, Ophthalmic anti-inflammatory agents

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 5 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018766s020lbl.pdf

Flurbiprofen Ophthalmic: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 5 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a611017.html

Flurbiprofen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 5 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a687005.html

Froben 50mg Tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 5 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/326/smpc

Ocufen - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 5 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/1343/smpc

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Information on this page was last updated on 9 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.