Fluconazole

Description

Fluconazole is an anti-fungal drug. It is used to prevent and treat infections caused by fungi and yeasts. It acts by stopping the growth and multiplication of these organisms.

Side effects

Major & minor side effects for Fluconazole

  • Headache
  • Nausea and Vomiting
  • Abdominal pain
  • Diarrhea
  • Skin rash
  • QT Prolongation
  • Alopecia
  • Seizures
  • Swelling of face, lips, eyelids, tongue, hands and feet

Uses of Fluconazole

What is it prescribed for?

  • Oropharyngeal Candidiasis
  • Esophageal Candidiasis
  • Cryptococcal Meningitis
  • Vaginal Candidiasis
  • Urinary Tract Infection
  • Peritonitis
  • Candidemia
  • Prophylaxis of Infections in Special Population
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-2 hours of oral administration.
  • Duration of effect
    The effect of this medicine lasts for an average of 30 hours. It may increase to 45 hours in elderly people.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If you use the medicine, you are advised to monitor the baby closely for any adverse effects.

Allergy

Fluconazole is not recommended for use if you have a known allergy to this medicine.

QT Interval prolonging drugs

Fluconazole is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If you use the medicine, you are advised to monitor the baby closely for any adverse effects.
General warnings

Liver Injury

Fluconazole can cause moderate to severe side effects on liver and may result in liver failure in rare cases. Any known incidence of liver disease should be reported to the doctor. Dosage adjustments and safety monitoring might be required in such cases.

Allergy

Fluconazole and other medicines of the same group i.e Azoles could cause allergy in some patients. Any such known instance of allergy should be reported to the doctor.

Skin disorders

Fluconazole may cause a condition where the skin starts to peel off in some patients. If you have had fungal infections in the past, then symptoms of infections should be monitored closely.

Heart condition

Caution is advised while using this medicine in patients with a history of cardiovascular disorder. Suitable dose adjustment and safety monitoring might be required in such cases.

Kidney disease

It is recommended to report any history of or active renal disorders to the doctor prior to the start of therapy with this medicine as necessary dosage adjustments may be made by the doctor for the safe use of this medicine.

Dizziness and seizures

This medicine may cause dizziness or even seizures in few patients. Hence caution is adviced while driving and operating heavy machinery after taking this medicine.

Other drugs and supplements

Fluconazole is known to interact with a large number of other medicines and hence it becomes mandatory for you to report the use of all of them to the doctor.

Birth control

Fluconazole may interact with the birth control pill you might be consuming and hence contraception might be ineffective. Alternate means of birth control are to be adopted while you are taking this medicine.

Geriatric use

Fluconazole must be used with caution in elderly since the effects are more severe, warranting an adjustment in dosage.

Missed Dose

Oral and topical forms: The missed dose of Fluconazole should be taken/used as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed one. Since Fluconazole injection is mostly administered by a healthcare professional in a clinical setting, the likelihood of missing a dose is very low.

Overdose

Oral and Topical forms: Seek emergency medical attention or contact your doctor in case of an overdose with Fluconazole. Injection: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Alprazolam

Atorvastatin

Cisapride

Clopidogrel

Erythromycin

Warfarin

Tretinoin

Disease interactions

Liver Disease

Fluconazole should be carefully administered in patients with impaired hepatic function. Suitable dosage adjustments and safety monitoring are necessary in such cases.

QT Prolongation

Fluconazole should be very carefully administered in patients with pre-existing heart conditions. Suitable dosage adjustments and safety monitoring are recommended in such cases.

Kidney disease

Fluconazole should be carefully administered in patients with impaired kidney function. Suitable dosage adjustments and safety monitoring are necessary in such cases.
Food interactions
Information not available.
Lab interactions
Information not available.
Fluconazole should be taken following all the instructions that are given by your doctor. To ensure complete recovery and no relapse, the full course of treatment should be followed. It is more effective if taken at the same time on all days. Any instance of side effect should be reported to the doctor immediately.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Fluconazole acts by stopping the production of a certain vital component for the fungi. This results in disruption of cell membrane formation process and growth of the organism are stunted.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Azole antifungals

Schedule

Schedule H

fluconazole | C13H12F2N6O - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3365#section=Top

DailyMed - fluconazole - fluconazole tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6ebf24fd-41cd-4b3c-8176-a1436253ba2d

Fluconazole - DrugBank [Internet]. Drugbank.ca. 2017 [cited 23 February 2017]. Available from:

https://www.drugbank.ca/drugs/DB00196

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~sgFUQe:1

DailyMed - fluconazole- fluconazole injection [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 16 October 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9843b969-33e1-4859-8eae-0055bb71d933

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Information on this page was last updated on 8 Feb 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.