Flexigesic S (50/10 mg) Tablet

Manufactured byInvision Medi Sciences
ContainsDiclofenac (50 mg) + Serratiopeptidase (10 mg)
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Description

Flexigesic S (50/10 mg) Tablet is a combination medicine used for the treatment of acute pain in adults.

Substitutes

List of substitutes for Flexigesic S (50/10 mg) Tablet

Side effects

Major & minor side effects for Flexigesic S (50/10 mg) Tablet

  • Constipation
  • Skin rash
  • Tinnitus
  • Anorexia
  • Abdominal pain
  • Diarrhea
  • Nausea and Vomiting
  • Loss of appetite
  • Gastrointestinal Bleeding

Uses of Flexigesic S (50/10 mg) Tablet

What is it prescribed for?

  • Mild to Moderate pain
  • Migraine
  • Bursitis
  • Tendinitis
  • Dysmenorrhea
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Concerns

Commonly asked questions

  • Onset of action
    The time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The time until which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, etc.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to diclofenac, any other NSAIDs, serratiopeptidase, or any other proteolytic enzymes.

Peptic Ulcer

This medicine is not recommended for use in patients with peptic ulcer disease due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Effect on heart

This medicine should be used with caution in patients with heart diseases due to the increased risk of adverse effects on the heart, especially after a prolonged use. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Coronary Artery Bypass Surgery

This medicine should not be taken to relieve pain before, during, or after a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.

Gastro-intestinal bleeding

This medicine may cause severe gastrointestinal bleeding and perforation after prolonged usage. These adverse events may occur with or without warning symptoms. This risk is especially higher in the elderly population and in patients with a history of gastrointestinal diseases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Long term use

Use of this medicine for more than 4 weeks is not advised since the safety and efficacy of long-term use are not clinically established.

Surgeries

The use of this medicine should be stopped at least 10-14 days before a scheduled surgery since it may increase the risk of bleeding during and/or after the procedure.

Liver diseases

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney diseases

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

The missed dose should be taken as soon as you remember. It is advisable to skip the missed dose if it is almost time for the next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, etc.
Interaction with Medicine

Methotrexate

Ramipril

Aspirin

Adefovir

Apixaban

Ketorolac

Disease interactions

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-sensitive asthma. Replacement with a suitable alternative should be done under your doctor's supervision.

Fluid Retention and edema

This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.

Gastro-Intestinal toxicity

This medicine may cause damage to the stomach, intestines, liver, etc., especially on prolonged use. Report any symptoms such as chronic indigestion, blood in stool or vomit, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Skin rash

This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Impaired kidney function

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Heart attack and Stroke

This medicine may cause a heart attack, stroke, or other associated symptoms after a prolonged use. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function is recommended for such patients. Report any symptoms such as a chest pain, shallow breathing, speech slurring, weakness, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Bleeding disorders

This medicine should be used with extreme caution in patients with any bleeding disorders due to the increased risk of excessive bleeding. Report any unusual bruising or bleeding to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities or for a longer duration than recommended. This medicine can be taken with food or after food to minimize the risk of stomach irritation. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Diclofenac works by reducing the formation of certain substances in the body that cause pain and swelling. Serratiopeptidase reduces inflammation and swelling through the breakdown of proteins.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Non-steroidal anti-inflammatory agents

Schedule

Schedule H

Serrapeptase | Ca7Zn+16 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 13 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/72941625#section=Top

Diclofenac | C14H11Cl2NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 23 February 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/3033

Diclofenac: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 6 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a689002.html

Toxnet [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 6 March 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~hjoI73:3

[Internet]. 2017 [cited 22 September 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019201s039s040lbl.pdf
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