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Fibator EZ Tablet

Manufactured bySUN PHARMA LABORATORIES LTD
ContainsAtorvastatin (10 mg) + Ezetimibe (10 mg) + Fenofibrate (160 mg)
Description

Fibator EZ Tablet is a combination medicine which may be used for the treatment of combined hyperlipidemia in patients with normal kidney and liver function. Patients are advised to maintain a strict exercise and diet regimen along with this medicine for the best possible effect.

Side effects

Major & minor side effects for Fibator EZ Tablet

  • Cough
  • Difficulty in swallowing
  • Difficulty in breathing
  • Sleeplessness
  • Headache
  • Dizziness
  • Loss of appetite
  • Stomach pain
  • Chills and fever
  • Itching and skin rash
  • Nausea and Vomiting
  • Weakness
  • Runny Nose
  • Increased sensitivity of the skin to sunlight

Uses of Fibator EZ Tablet

What is it prescribed for?

  • Combined hyperlipidemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to atorvastatin, ezetimibe, fenofibrate or any other inactive ingredients present along with the formulation.

Active liver disease

This medicine is not recommended for use in patients with active liver diseases or any abnormality in the liver function tests due to the increased risk of severe adverse effects.

Severe renal impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of serious adverse effects.

Gallbladder disease

This medicine is not recommended for use in patients with a known history of gallbladder diseases due to the increased risk of gallbladder stones.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Cognitive impairment

This medicine may cause forgetfulness, memory loss, and confusion in some patients. These symptoms usually disappear gradually once the use of the medicine is discontinued.

Increase in blood sugar levels

This medicine may cause an increase in the blood glucose levels along with an increase in the Glycated Hemoglobin levels. This risk is especially higher in patients with a history of diabetes mellitus. Close monitoring of blood glucose levels, appropriate corrective measures, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Muscle degradation and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition.

Heavy alcohol consumption

This medicine may cause liver and kidney related problems if you consume alcohol very frequently in large quantities during treatment with this medicine.

Coumarin Anticoagulants

This medicine should be used with caution in patients receiving coumarin anticoagulants such as warfarin due to the increased risk of bleeding. Close monitoring of International Normalized Ratio (INR) is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Cholelithiasis

This medicine is not recommended for use in patients with gallbladder diseases due to the increased risk of gallbladder stones. Replacement with a suitable alternative should be considered based on the clinical condition.

Hematologic Changes

This medicine should be used with caution due to the increased risk of a decrease in the hemoglobin, hematocrit, and white blood cell count levels. Close monitoring of complete blood count is recommended in patients receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Increase in serum creatinine levels

Use of this medicine may increase serum creatinine levels. Close monitoring of kidney function is recommended in patients receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clarithromycin

Erythromycin

Azithromycin

Atazanavir

Cyclosporine

Cholestyramine

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with liver diseases due to the increased risk of serious adverse effects. It is not recommended for use in patients with active liver diseases or persistent elevation of transaminase levels. Close monitoring of liver function tests or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Cognitive Impairment

This medicine should be used with caution in patients with a history of cognitive impairment since it may worsen the patient's condition. Close monitoring of the patient for any changes in mood or behavior is recommended. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood sugar levels. Close monitoring of blood sugar levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Rhabdomyolysis

This medicine is not recommended for use in patients with a known history of Rhabdomyolysis due to the increased risk of kidney failure and death. Replacement with a suitable alternative should be considered under your doctor's supervision.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects. These side effects may include muscle pain and weakness, fever, chills, swelling of joints, skin rash, nausea, vomiting, etc.
Lab interactions
Information not available.
Take this medicine as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Atorvastatin reduces the level of cholesterol in the blood. Ezetimibe works by reducing or stopping the absorption of cholesterol through the small intestine. Fenofibrate increases the natural lipid breakdown process with the help of the enzyme lipoprotein lipase. This removes the bad cholesterol (LDL) and triglycerides from the blood and increases the levels of good cholesterol (HDL).
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Statins, Cholesterol absorption inhibitors, Fibric acid derivatives, Antihyperlipidemic combinations

Schedule

Schedule H

Fenofibrate - DrugBank [Internet]. Drugbank.ca. 2017 [cited 4 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01039

Fenofibrate: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 4 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a601052.html

Atorvastatin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 6 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a600045.html

Ezetimibe: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603015.html

Ezetimibe: DrugBank [Internet]. Drugbank.ca. 2017 [cited 23 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00973
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Information on this page was last updated on 3 Jul 2019

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