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Farabine 20 mg/20 ml Injection

Manufactured byINTAS PHARMACEUTICALS LTD
ContainsClofarabine
Description

Farabine 20 mg/20 ml Injection is used for the treatment of acute lymphoblastic leukemia (ALL), a type of blood cancer where the bone marrow produces cancerous and immature lymphoblasts in large quantities. It is used in children and adult patients aged up to 21 years and who have not adequately responded to other anticancer therapies (at least 2 therapies).

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Substitutes

List of substitutes for Farabine 20 mg/20 ml Injection

Cfara 20 mg/20 ml Injection
Zydus Cadila

Side effects

Major & minor side effects for Farabine 20 mg/20 ml Injection

  • Abdominal and stomach pain
  • Black or Tarry stools
  • Bleeding gums
  • Blurred vision
  • Chills
  • Confusion
  • Diarrhea
  • Headache
  • Painful cold sores or blisters
  • Nausea and Vomiting
  • Bloating
  • Constipation
  • Indigestion

Uses of Farabine 20 mg/20 ml Injection

What is it prescribed for?

  • Acute Lymphoblastic Leukemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Use of ethanol along with Farabine 20 mg/20 ml Injection may increase the risk of liver damage. Report to your doctor if you experience any signs and symptoms like vomiting, nausea, pale stools, skin rash, itching, loss of appetite, yellowing of skin or eyes, dark urine, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Clofarabine or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Bonemarrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Infections

Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

Missed Dose

This medicine is usually given in a clinical setting so the likelihood of missing a dose is very less. If you miss any chemotherapy session you should contact your doctor immediately and fix an appointment as recommended by your doctor.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Use of ethanol along with Farabine 20 mg/20 ml Injection may increase the risk of liver damage. Report to your doctor if you experience any signs and symptoms like vomiting, nausea, pale stools, skin rash, itching, loss of appetite, yellowing of skin or eyes, dark urine, etc.
Interaction with Medicine

Febuxostat

Live attenuated vaccines and related products

Abacavir

Alemtuzumab

Disease interactions

Sepsis

This medicine may cause kidney failure in patients with active infections, tumor lysis syndrome, or sepsis. Close monitoring of kidney function is necessary for such patients while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by slowing or stopping the growth of cancer cells in the body.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Antimetabolites

Schedule

Schedule H

DailyMed - Clofarabine - clofarabine injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 28 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4bd27f6-2454-bad3-6e4d-78e4a99fbe7a

Clofarabine - DrugBank [Internet]. Drugbank.ca. 2019 [cited 28 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB00631

Clofarabine Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 28 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a607012.html

Clofarabine 1 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 28 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/8551/smpc
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Information on this page was last updated on 31 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.