Etoposide

Description

Etoposide is an anticancer medicine used in combination with other medicines to treat cancer of the testicles and ovaries and certain cancers of the lungs, blood, and lymphatic system.

Side effects

Major & minor side effects for Etoposide

  • Nausea and Vomiting
  • Hair loss
  • Loss of appetite
  • Decrease in blood cell count
  • Anemia
  • Low blood pressure
  • Abnormal Liver function
  • Heart attack
  • Infections
  • Rash

Uses of Etoposide

What is it prescribed for?

  • Small Cell Lung Cancer
  • Testicular Cancer
  • Acute Myeloid Leukemia
  • Hodgkin's Lymphoma
  • Ovarian Cancer
  • Non-Hodgkin's Lymphoma
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to etoposide or any other inactive ingredients present along with this medicine.

Severe myelosuppression

This medicine is not recommended for use in patients with a severe bone marrow suppression (WBC less than 2,000 cells/mm3 or platelet count less than 75,000 cells/mm3) not due to malignant disease since it may worsen the patient's condition.

Live vaccines

Administration of live vaccines is contraindicated during treatment with this medicine due to the increased risk of serious adverse effects including life-threatening infections and death.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.
General warnings

Myelosuppressuion

This medicine may cause significant bone marrow suppression in some patients. This increases the risk of life-threatening infections and other associated complications. Close monitoring of blood cell counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Anaphylactic reactions

This medicine may cause severe hypersensitivity or anaphylactic reactions in some patients. The symptoms of such reactions may include chills, fever, increased heart rate, breathing difficulties, low blood pressure, etc. Close monitoring of the patient for any such reactions is recommended during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Pediatric Use

This medicine should be used with extreme caution in patients below 18 years of age since there is limited information on the use of this medicine in such patients.

Rapid intravenous injection

Etoposide is intended for slow intravenous infusion only. It must not be given by rapid intravenous injection. Rapid intravenous injections of this medicine may cause serious abnormalities in heart rate and other cardiac toxicities.

Drowsiness

This medicine may rarely cause drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience drowsiness during treatment with this medicine.

Missed Dose

If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Do not double the dose to make up for the missed one.

Overdose

The injection form of this medicine is usually administered in the clinic/hospital setting. Hence, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated if an overdose is suspected. If you suspect an overdose with the oral form of this medicine, contact your doctor immediately for further instructions or visit the nearest emergency room.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Phenobarbital

Live attenuated vaccines and related products

Adalimumab

Phenytoin

Carboplatin

Clozapine

Disease interactions

Infections

This medicine is not recommended for use in patients with active infections since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Myelosuppression

This medicine should be used with extreme caution in patients with known myelosuppression since it may worsen the patient's condition. Close monitoring of blood cell counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Carefully follow all instructions given by your doctor and report any severe undesirable side effects to the doctor immediately. Do not consume the oral form of this medicine in larger or smaller quantities than recommended. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine prevents the growth and spread of cancer cells in the body. This slows down the progression of the disease.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Podophyllotoxins

Schedule

Schedule H

DailyMed - Etoposide capsule [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 15 January 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=508a418e-985f-4208-9324-2230655bb5c2

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 15 January 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2011-PI-03706-3

[Internet]. 2018 [cited 15 January 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6916.pdf?filename=PIL.6916.pdf

[Internet]. Tevauk.com. 2018 [cited 15 January 2018]. Available from:

http://www.tevauk.com/mediafile/id/44116.pdf

[Internet]. Just.edu.jo. 2018 [cited 15 January 2018]. Available from:

http://www.just.edu.jo/ar/DIC/ClinicGuidlines/Hodgkin%20Lymphoma%20treatment%20regimens.pdf

[Internet]. Londoncanceralliance.nhs.uk. 2018 [cited 15 January 2018]. Available from:

http://www.londoncanceralliance.nhs.uk/media/41671/Gynae_Ovarian_or_cervix_Etoposide_Oral_protocol_V2.0.pdf

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 22 Feb 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.