Ethionamide

Description

Ethionamide is an antimycobacterial medicine used to treat tuberculosis. It is generally used in patients who have acquired resistance to other anti-tubercular medicines. It is usually taken in a combination with other medicines to treat all types of Mycobacterium tuberculosis. This medicine is not recommended for use in children below 12 years of age since the safety and efficacy of use are not clinically established.

Side effects

Major & minor side effects for Ethionamide

  • Confusion
  • Depressed mood
  • Yellowing of skin or eyes
  • Changes in vision
  • Fever
  • Joint pain
  • Weight gain
  • Itching or rash
  • Dry skin
  • Nausea and Vomiting
  • Stomach pain
  • Diarrhea
  • Metallic taste
  • Loss of appetite
  • Headache
  • Weakness
  • Dizziness and Drowsiness

Uses of Ethionamide

What is it prescribed for?

  • Tuberculosis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to ethionamide or any other inactive ingredients present along with it.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
General warnings

Liver Diseases

This medicine should be used with extreme caution in patients suffering from mild to moderate liver diseases or patients at risk of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver diseases.

Driving or Operating machinery

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a mycobacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Use in children

This medicine is not recommended for use in children below 12 years of age since the safety and efficacy of use are not clinically established. However, if the child is resistant to primary therapy and is suffering from life-threatening complications, your doctor may prescribe this medicine. Close monitoring of the clinical condition is advised in such cases.

Liver enzyme levels

This medicine may elevate liver enzyme levels in some patients. Close monitoring of liver enzyme levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Live cholera vaccine

Teriflunomide

Rifampicin

Disease interactions

Liver Disease

This medicine is not recommended for use in patients with severe liver diseases or a known history of liver injury due to the use of this medicine. In patients with mild to moderate liver diseases, close monitoring of liver function tests is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in these patients based on their clinical condition.

Peripheral Neuropathy

This medicine should be used with caution in patients with a known history of peripheral neuropathy due to the increased risk of worsening of the patient's condition. Appropriate corrective measures including vitamin B6 supplementation, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as directed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Complete the course of treatment to prevent the spread of the infection. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It stops the growth of bacteria by interfering with the cell wall synthesis.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Nicotinic acid derivatives, Antituberculosis agents

Schedule

Schedule H1

Ethionamide [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/2761171

Ethionamide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00609

DailyMed - Ethionamide tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=04a413fe-95f4-47a7-42ac-283a9e78297d

[Internet]. Extranet.who.int. 2018 [cited 14 September 2018]. Available from:

https://extranet.who.int/prequal/sites/default/files/TB207part3.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 14 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/013026s029lbl.pdf

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Information on this page was last updated on 8 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.