Estriol

Description

The primary ingredient of Estriol is available as oral and topical forms. This medicine is used for the treatment of problems arising due to diminished estrogen production after the menopause (usually around the age of 50) and after surgical removal of the ovary. It also promotes wound healing before or after vaginal surgery.

Side effects

Major & minor side effects for Estriol

  • Headache
  • Skin rash
  • Breast enlargement
  • Feeling very tired or weak
  • Vaginal discharge
  • Nausea and vomiting

Uses of Estriol

What is it prescribed for?

  • Postmenopausal symptoms
  • Before and After vaginal surgery
  • After ovarian surgery
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women.

Allergy

This medicine is not recommended for use in patients who have a known allergy to estriol, any estrogen products or any other ingredient present along with it.

Breast cancer

This medicine is not recommended for use in patients having breast cancer. It should also not be used if a patient has had breast cancer before or is suspected of having it.

Estrogen-dependent tumor

This medicine is not recommended for use in patients having cancer which is attributed to abnormal levels of the hormone estrogen in the body for a prolonged duration.

Liver disease

This medicine is not recommended for use in patients with liver diseases due to the increased risk of worsening of the patient's condition.

Unexplained vaginal bleeding

This medicine is not recommended for use if you have an abnormal episode of vaginal bleeding which was not diagnosed.

Heart and blood vessel disorder

This medicine is not recommended for use in patients having a disease of the heart or blood vessels viz. deep vein thrombosis, recent heart attack, other blood clotting disorders, etc.

Endometrial hyperplasia

This medicine is not recommended for use in patients with endometrial hyperplasia (a condition of excessive thickening of the womb lining) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women.
General warnings

Asthma

This medicine should be used with caution in patients with asthma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes (increased blood sugar levels) due to the increased risk of worsening of the patient's condition. Close monitoring of blood sugar levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Cardiovascular risks

This medicine has been associated with an increased risk of stroke, heart attack, and other complications associated with the heart. It should be used with caution in patients having heart disease or are exposed to the risk factors.

Jaundice like symptoms

This medicine may cause yellowing of the eyes and skin due to its effect on the liver and the gall-bladder. Report the presence of any symptom indicative of jaundice to the doctor on priority. Use of this medicine should be stopped in such cases.

Gall bladder disease

Use of this medicine can increase the risk of gallbladder diseases, especially in postmenopausal women. It should be used with caution in patients suffering from a disease of the gall bladder. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Missed Dose

Tablet: Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped. Cream: Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Corticosteroids

Griseofulvin

Nevirapine

Carbamazepine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Tablet: Take this medicine exactly as instructed by the doctor. Do not take this medicine in larger or smaller quantities or for longer durations than recommended. It is advised to do a regular follow-up with the doctor while taking this medicine. Cream: Apply this medicine to the affected area as instructed by the doctor. Follow all the usage instructions mentioned on the label or the package insert. Do not apply in larger or smaller quantities than recommended. Do not cover the application area with bandages or other coverings unless specifically instructed by the doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by replacing or replenishing the hormone estrogen that is normally produced in the body.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Estrogens

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2019 [cited 2 January 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.5384.pdf

Estriol - DrugBank [Internet]. Drugbank.ca. 2019 [cited 2 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB04573

Estriol [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 2 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/estriol

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Information on this page was last updated on 20 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.