Estramustine

Description

Estramustine is an anti-cancer medicine used in men for the treatment of prostate cancer that has progressed or spread to other parts of the body. This medicine is not recommended for use in females, children, and adolescents.

Side effects

Major & minor side effects for Estramustine

  • Diarrhea
  • Stomach upset
  • Black or tarry stools
  • Headache
  • Shortness of breath
  • Changes in vision
  • Skin rash
  • Nausea and vomiting

Uses of Estramustine

What is it prescribed for?

  • Prostate Cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in women.
  • Usage while breast-feeding?
    This medicine is not recommended for use in women.

Allergy

This medicine is not recommended for use in patients with a known allergy to Estramustine or any other inactive ingredients present along with this medicine.

Thromboembolic disorders

This medicine is not recommended for use in patients with thromboembolic disorders except in cases where the thromboembolic phenomenon has resulted from a tumor mass.
Warnings for special population

Pregnancy

This medicine is not recommended for use in women.

Breast-feeding

This medicine is not recommended for use in women.
General warnings

Use in females children, and adolescents

This medicine is not recommended for use in females, children, and adolescents.

Gynecomastia and impotence

This medicine may cause gynecomastia (enlarged breast in men) and impotence in some patients.

Angioedema

This medicine may cause swelling of the face, eyes, lips, tongue, throat, hands and feet in some patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Driving or Operating machinery

Use of this medicine may cause dizziness, tiredness, or visual disturbances in some patients. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Prednisolone

Quinapril

Tranexamic Acid

Disease interactions

Hypertension

This medicine should be used with extreme caution in patients with hypertension due to the risk of worsening of the patient's condition. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypercalcemia

This medicine should be used with extreme caution in patients with hypercalcemia (increased calcium levels in the blood) due to the risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Fluid retention

This medicine should be used with caution in patients having fluid retention disorders due to the increased risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Thyroid disorders

This medicine should be used with caution in patients suffering from thyroid diseases due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Consumption of food and milk along with this medicine may alter the desired effects of Estramustine. Therefore, it is advised to take this medicine one hour before or after food.
Lab interactions
Information not available.
Take this medicine one hour before or after food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine blocks the cancer cells from multiplying and stops their growth.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Antineoplastics, Mitotic inhibitors

Schedule

Schedule H

Estramustine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB01196

DailyMed - Emcyt- estramustine phosphate sodium capsule [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9b01bc6-95ac-46f9-befa-d845a74d53c1

Estracyt Capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 10 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/1082

[Internet]. Accessdata.fda.gov. 2018 [cited 10 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018045s023lbl.pdf

Estramustine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 26 February 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a608046.html

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Information on this page was last updated on 26 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.