Esomeprazole

Description

Esomeprazole is an anti-ulcer medicine used to treat conditions where the stomach produces too much acid. Stomach and duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome are certain problems caused by high levels of stomach acid. It relieves stress ulcers and also acidity due to the intake of painkillers. Esomeprazole is used in combination with antibiotics like amoxicillin and clarithromycin to prevent ulcers caused by Helicobacter pylori bacteria. Esomeprazole interferes with the final step of acid release in the stomach. Thus, acidity in the stomach is decreased and the ulcer healing process is fastened. Common side effects of Esomeprazole are nausea, vomiting, headache, stomach pain, diarrhoea, and dizziness. Do not use this medicine if you are previously allergic to it. You may have to take Esomeprazole one hour before a meal. Avoid spicy and fatty foods, alcohol, and reduce caffeinated drinks or beverage such as coffee, tea and cola while using this medicine. Eat a healthy and balanced diet. Always try to finish your dinner three hours before heading to bed.

Side effects

Major & minor side effects for Esomeprazole

  • Headache
  • Nausea and vomiting
  • Excessive gas in stomach
  • Stomach pain
  • Skin rash
  • Difficulty in breathing
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Irregular heartbeat
  • Diarrhoea
  • Unusual tiredness and weakness
  • Acid or sour stomach
  • Decreased appetite

Uses of Esomeprazole

What is it prescribed for?

  • Erosive Esophagitis
  • Gastroesophagal Reflux Disease
  • Helicobacter pylori Infection
  • Zollinger-Ellison Syndrome
  • Gastric and duodenal ulcers
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Concerns

Commonly asked questions

  • Onset of action
    Esomeprazole begins its action within an hour of taking it. You will start to feel better in 2-3 days and it may take 4-5 weeks for complete relief.
  • Duration of effect
    After administration, the effect of esomeprazole remains in the body for an average duration of 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported for Esomeprazole.
  • Usage in pregnancy?
    Esomeprazole is usually not recommended in pregnant women. It is not known to cause any birth defects. However, it should only be used upon your doctor's recommendation if there are no alternatives and the benefit outweighs the risk.
  • Usage while breast-feeding?
    Esomeprazole may pass into breast milk and cause side effects in breastfed babies. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant. If required, it should only be used upon your doctor's recommendation.

Allergy

Avoid taking Esomeprazole if you are previously allergic to it. Allergic reactions are very rare to this medicine. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling of the face/tongue/throat), breathing difficulties, etc.
Warnings for special population

Pregnancy

Esomeprazole is usually not recommended in pregnant women. It is not known to cause any birth defects. However, it should only be used upon your doctor's recommendation if there are no alternatives and the benefit outweighs the risk.

Breast-feeding

Esomeprazole may pass into breast milk and cause side effects in breastfed babies. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant. If required, it should only be used upon your doctor's recommendation.
General warnings

Driving or operating machinery

Esomeprazole may cause sleepiness or dizziness. Hence it is advised not to drive vehicles and operate heavy machinery after taking this medicine.

Lupus erythematosus

Lupus erythematosus is an autoimmune disease that affects the skin, kidneys, brain, joints, and other organs. It occurs when the immune system of the body attacks its own tissues. Lupus may occur or gets worse while using Esomeprazole. Inform your doctor immediately if you experience tiredness, painful joints, rashes, or lesions on the skin while using this medicine.

Atrophic gastritis

In some patients, continuous use of Esomeprazole may cause swelling of the stomach mucosa lasting for a longer duration. Hence use this medicine only for the prescribed period of time.

Bone fractures

Long term use of Esomeprazole decreases the calcium absorption in the body leading to reduced bone density (thinning of bones). Calcium is essential for bone formation and its deficiency can increase the risk of bone fractures. Take calcium supplements or increase the intake of calcium in your diet to avoid bone thinning. Using Vitamin D supplements along with Esomeprazole can help to increase calcium absorption in the body.

Vitamin B12 deficiency

Long-term treatment with Esomeprazole may decrease the absorption of Vitamin B12 in the body. You should take vitamin B12 supplements if this medicine is used for more than 3 years.

Hypomagnesemia

Prolonged use of Esomeprazole may result in low magnesium levels in the blood (hypomagnesemia). Inform your doctor in case of dizziness, irregular heartbeat, shivering, muscle pain, seizures or fits. You may have to check magnesium levels in the blood at regular intervals.

Missed Dose

Oral forms: Try not to skip the scheduled dose of esomeprazole. If it's time for the next dose, do not double the dose. Injection: Esomeprazole is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Oral forms: Seek emergency medical attention or contact the doctor in case of overdose. Injection: Since esomeprazole is administered in the hospital or clinical setting by a qualified healthcare professional, the chances of an overdose are very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clopidogrel

Methotrexate

Warfarin

Nelfinavir

Digoxin

Fluconazole

Disease interactions

Liver Disease

The primary conversion of Esomeprazole to its active form happens in the liver. Therefore patients with liver diseases need special consideration while taking Esomeprazole.

Osteoporosis

Osteoporosis is a bone disease in which bones become weak and fragile (may break from a fall). Long term use of Esomeprazole can reduce bone density (thinning of bones). Calcium is essential for bone formation. This medicine decreases the calcium absorption in the body leading to calcium deficiency. Take calcium supplements or increase the intake of calcium in your diet to avoid bone thinning. Using Vitamin D supplements along with Esomeprazole can help to increase calcium absorption in the body.

Colitis

Esomeprazole may cause diarrhoea. Use this medicine with extreme caution in patients with gastrointestinal (mouth to anus) diseases, particularly colitis (swelling of the inner lining of the colon), since it may cause severe diarrhoea.
Food interactions
Take Esomeprazole at least 1 hour before meals as the food may reduce the absorption of the medicine.
Lab interactions
Information not available.
Esomeprazole uses for reducing stomach acid production is effective. Esomeprazole composition comprises esomeprazole salt that helps to treat conditions where the stomach produces too much acid. Oral forms: Take esomeprazole as instructed by your doctor. Avoid spicy and fatty foods, alcohol, and reduce caffeinated drinks or beverage such as coffee, tea and cola while using this medicine. Eat a healthy and balanced diet. Always try to finish your dinner three hours before heading to bed. Injection: Esomeprazole should be administered by a qualified healthcare professional in the clinical or hospital setting.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Esomeprazole reduces the production of acid in the stomach. It stops the action of the proton pumps that are found on cells that line the stomach, which decreases stomach acid production.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Proton pump inhibitors, Anti-Ulcer Agents

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2021. DailyMed - ESOMEPRAZOLE capsule. [online] Available at: < [Accessed 2 March 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7a7b80f1-fd8a-a78f-e053-2991aa0a7098>

Pubchem.ncbi.nlm.nih.gov. 2021. Esomeprazole. [online] Available at: < [Accessed 2 March 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Esomeprazole>

Drugs, H., 2021. Esomeprazole: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 2 March 2021].

https://medlineplus.gov/druginfo/meds/a699054.html>

Medicines.org.uk. 2021. Esomeprazole 20 mg gastro-resistant capsules, hard - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 2 March 2021].

https://www.medicines.org.uk/emc/product/12019/smpc>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 2 March 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022101s014021957s017021153s050lbl.pdf>

Go.drugbank.com. 2021. Esomeprazole | DrugBank Online. [online] Available at: < [Accessed 2 March 2021].

https://go.drugbank.com/drugs/DB00736>

Medicalinformation.astrazeneca-us.com. 2021. NEXIUM® (esomeprazole magnesium) Prescribing Information | AZ Medical Information. [online] Available at: < [Accessed 2 March 2021].

https://medicalinformation.astrazeneca-us.com/home/prescribing-information/nexium-pi.html>

Sunpharma.com. 2021. [online] Available at: < [Accessed 2 March 2021].

https://www.sunpharma.com/australia-pi-download/50520/Esomeprazole>

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Information on this page was last updated on 4 Mar 2021

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