Epalrestat

Description

Epalrestat is an aldose reductase inhibitor used for the treatment of diabetic peripheral neuropathy, one of the most common long-term complications in patients suffering from diabetes mellitus.

Side effects

Major & minor side effects for Epalrestat

  • Nausea and vomiting
  • Irregular heart beat
  • Diarrhea
  • Abdominal pain
  • Dry mouth
  • Weakness and general discomfort
  • Chills
  • Dizziness
  • Headache
  • Rash

Uses of Epalrestat

What is it prescribed for?

  • Diabetic Peripheral Neuropathy
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to epalrestat or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Driving or operating machines

This medicine may cause dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience dizziness during treatment with this medicine.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. You are advised to take this medicine before food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine reduces the levels of sorbitol which is responsible for damage to the nerves.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Aldose reductase inhibitor

Schedule

Schedule H

[Internet]. Pdfs.semanticscholar.org. 2018 [cited 9 April 2018]. Available from:

https://pdfs.semanticscholar.org/4759/1bb62346cee5cd9d69c40a67c68ca777ff1f.pdf

[Internet]. Pharmrev.aspetjournals.org. 2018 [cited 9 April 2018]. Available from:

http://pharmrev.aspetjournals.org/content/pharmrev/64/4/880.full.pdf

NL R. Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2018 [cited 9 April 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/18447661

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Information on this page was last updated on 25 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.