Enzalutamide
Description
Enzalutamide is used to treat castrate-resistant prostate cancer (CRPC), a stage where prostate cancer keeps growing even when there are very low levels of testosterone in the body. It is mainly used in patients whose disease has progressed on or after Docetaxel therapy. This medicine is not recommended for use in females, children, and adolescents.
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Side effects
Major & minor side effects for Enzalutamide
- Blood in urine
- Difficulty in breathing
- Back pain
- Blurred vision
- Chest pain
- Difficult or painful urination
- Weight loss
- Muscle weakness
- Dry skin
- Decreased appetite
- Headache
- Diarrhea
- Nausea
Uses of Enzalutamide
What is it prescribed for?
- Castrate-resistant prostate cancer (CRPC)
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendency has been reported.
- Usage in pregnancy?This medicine is not recommended for use in women.
- Usage while breast-feeding?This medicine is not recommended for use in women.
Allergy
This medicine is not recommended for use in patients with a known allergy to Enzalutamide or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in women.
Breast-feeding
This medicine is not recommended for use in women.
General warnings
Posterior reversible encephalopathy syndrome (PRES)
This medicine may cause a neurological disorder called posterior reversible encephalopathy syndrome characterized by symptoms such as seizures, headache, visual loss, altered mental status, confusion, etc in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Use in females children, and adolescents
This medicine is not recommended for use in females, children, and adolescents.
Falls and fractures
This medicine may increase the risk of falls and fractures in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Driving or Operating machinery
Use of this medicine may cause dizziness, drowsiness, tiredness, seizures, or visual disturbances in some patients. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms during treatment with this medicine.
Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Dexamethasone
Pimozide
Verapamil
Clozapine
Disease interactions
Kidney impairment
This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Seizures
This medicine should be used with caution in patients with seizures due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine acts by blocking the action of male hormones on the prostate gland, thereby stopping the growth and spread of cancer cells.
Legal Status
Classification
Category
Antineoplastics, Antiandrogens
Schedule
Schedule H
[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 19 December 2018]. Available from:
[Internet]. Drugbank.ca. 2018 [cited 19 December 2018]. Available from:
[Internet]. Medlineplus.gov. 2018 [cited 19 December 2018]. Available from:
[Internet]. Accessdata.fda.gov. 2018 [cited 19 December 2018]. Available from:
[Internet]. Ema.europa.eu. 2018 [cited 19 December 2018]. Available from:
Information on this page was last updated on 25 Feb 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.