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Envas H (5/12.5 mg) Tablet
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Envas H (5/12.5 mg) Tablet

Manufactured byCadila Pharmaceuticals Ltd.
ContainsEnalapril (5 mg) + Hydrochlorothiazide (12.5 mg)
Description
Envas H (5/12.5 mg) Tablet is a combination medicine used for the treatment of high blood pressure. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Envas H (5/12.5 mg) Tablet

  • Increased urination
  • Itching
  • Abdominal and stomach pain
  • Dry mouth
  • Joint pain, stiffness, and swelling
  • Cramping
  • Weakness
  • Blurred vision
  • Confusion
  • Dizziness when getting up suddenly from a sitting position
  • Cough
  • Chest pain
  • Fever or chills
  • Skin rash
  • Increase in the potassium levels

Uses of Envas H (5/12.5 mg) Tablet

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to shows its effect is about 1 hour.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 12 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to hydrochlorothiazide, other sulfonamides, enalapril, or other ACE inhibitors.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

Aliskiren

Coadministration of aliskiren and this combination medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl =< 30 ml/min/1.7 m2) due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hepatic dysfunction

This medicine should be used with extreme caution in patients with liver dysfunction due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition.

Volume and electrolyte depletion

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal diseases

This medicine may cause Azotemia in patients with a known history of severe renal diseases. Close monitoring of kidney function is necessary while taking this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Hypotension

Symptomatic hypotension may occur in patients with volume depletion or patients who are treated with high-dose diuretics. It is advised to correct this condition before initiating treatment with this combination medicine.

Hyperkalemia

This medicine may increase the potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Pediatric population

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Cough

This medicine may cause a persistent nonproductive cough in some patients. It is resolved when the medicine is discontinued.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Losartan

Corticosteroids

Aliskiren

Insulin

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with a history of gout or chronic renal failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Angioedema

This medicine is not recommended for use in patients with a history of angioedema or a family history of angioedema due to the increased risk of recurrent symptoms. Report any incidence of swelling of the face, lips, and eyes to the doctor on priority. Replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Hydrochlorothiazide increases the excretion of water and sodium through the urine. Enalapril relaxes the blood vessels and promotes the smooth flow of blood. Their combination is thus effective in reducing the blood pressure.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

ACE inhibitors with thiazides, Antihypertensive combinations

Schedule

Schedule H

Hydrochlorothiazide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00999

DailyMed - Hydrochlorothiazide tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7b38ac8a-4540-4eb2-aedd-9aa966d22190

[Internet]. 2017 [cited 28 July 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf

Enalapril: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 27 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a686022.html
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Information on this page was last updated on 10 Oct 2017

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.