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Entrogyl Syrup
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Entrogyl Syrup

Manufactured byCIPLA LTD
ContainsNorfloxacin (100 mg) + Metronidazole (100 mg)
Description
Entrogyl Syrup is a combination of Norfloxacin and Metronidazole. It is used in the treatment of infections of the stomach, intestines and urinary tract. This medicine is mainly used in children with infections caused by parasites (an organism living in another organism for its survival). Entrogyl Syrup works by stopping the growth of microorganisms responsible for infections. Entrogyl Syrup may show some common side effects such as stomach pain, difficulty in sleeping, headache, nausea, vomiting etc. Consult your child's doctor if these side effects persist. Do not give this medicine if your child is allergic to it. Entrogyl Syrup is taken on an empty stomach, as prescribed by your doctor. Try giving this medicine at the same time every day to maintain a constant level of medicine in your child's body. Finish the entire course of treatment even if your child starts to feel better, to avoid antibiotic resistance. Entrogyl Syrup is not recommended to be used in infants below 6 months of age. Inform your doctor about all the pre-existing conditions and your child's current medications to avoid any side effects. If you are pregnant or breastfeeding, consult your doctor before taking this medicine.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Entrogyl Syrup

  • Diarrhoea
  • Fever
  • Nausea and vomiting
  • Joint or muscle weakness
  • Stomach pain
  • Change in taste/ Metallic taste
  • Headache
  • Difficulty in sleeping
  • Loss of appetite
  • Skin rash

Uses of Entrogyl Syrup

What is it prescribed for?

  • Intestinal amoebiasis
  • Diarrhoea
  • Infections of urinary tract
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken by Entrogyl Syrup to show its effect is not clinically known.
  • How long do the effects of this medicine last?
    The duration for which Entrogyl Syrup stays in your body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended along with Entrogyl Syrup therapy as it can worsen your side effects. Any symptoms of a fast heartbeat, warmth, headache and breathing difficulty should be reported to your doctor.
  • Is this a habit forming medicine?
    Entrogyl Syrup has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Entrogyl Syrup is only for use in children.
  • Can this medicine be taken while breast-feeding?
    Entrogyl Syrup is only for use in children.

Allergy

Entrogyl Syrup is not recommended for use if your child is allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, swelling and/or itching (especially in the face, lips, throat), breathing difficulty, etc.

Use in children below 6 months of age

Use of Entrogyl Syrup is not recommended for children below 6 months of age as the safety and efficacy data of this medicine for that age group is not clinically established.

Tendinitis

Tendinitis is a condition where the connective tissues between your muscles and bones (tendons) become inflamed. Avoid taking Entrogyl Syrup if you have this condition as this medicine can compromise your tendon function and increase the risk of injury, especially in your weight-bearing joints.
Warnings for special population

Pregnancy

Entrogyl Syrup is only for use in children.

Breast-feeding

Entrogyl Syrup is only for use in children.
General warnings

Liver disease

Entrogyl Syrup is converted in liver to become active. This medicine should be used cautiously as an affected liver will not properly convert the medicine into its active form. This can increase the chance of side effects and toxicity. Your doctor can adjust your dose or replace it with a suitable medicine if required.

Antibiotic resistance

Incomplete course of Entrogyl Syrup may cause antibiotic resistance (ability of bacteria to defeat the antibiotic). Ensure to complete the entire course even if your child starts feeling well.

Myasthenia gravis

Myasthenia gravis is a long-term condition that leads to varying degrees of skeletal muscle (muscles attached with bones) weakness and fatigue. Entrogyl Syrup is not recommended to be used as it can worsen your condition.

Missed Dose

Give Entrogyl Syrup as soon as you remember. If it is time for the next dose, skip the missed dose and resume to the scheduled time. Do not double the dose to make the missed dose.

Overdose

Consult your doctor in case you suspect an overdose of Entrogyl Syrup.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended along with Entrogyl Syrup therapy as it can worsen your side effects. Any symptoms of a fast heartbeat, warmth, headache and breathing difficulty should be reported to your doctor.
Interaction with Medicine

Antacids containing calcium/magnesium/aluminum

Warfarin

Aspirin

Disease interactions

QT Prolongation

Entrogyl Syrup may cause a heart rhythm problem called prolonged QT intervals (an electrical heartbeat disturbance) if you are taking heart medications. It may result in fast, rapid, and irregular heartbeats. Your doctor may closely monitor you and/or adjust your dose as required.

Colitis

Take Entrogyl Syrup with extreme caution if you have gastrointestinal (stomach and intestines) diseases, particularly colitis (swelling of the inner lining of the colon), as it may worsen your condition. Ask your doctor for dose adjustments or another suitable medicine in such cases.

Kidney Disease

Take Entrogyl Syrup cautiously if you have kidney problems as an affected kidney will not filter this medicine properly. This can increase the risk of kidney damage. Dose adjustments may be required, based on your clinical condition.
Food interactions
Entrogyl Syrup will not show its desired effects if consumed with dairy products. At least two hours gap should be maintained between this medicine and dairy products.
Avoid using Entrogyl Syrup along with multivitamins with minerals. It can be taken before 2 to 4 hours of taking multivitamins with minerals or after 4 to 6 hours of taking it.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Give Entrogyl Syrup as directed by your doctor. All of the instructions/directions on the label/package insert must be followed. Shake well before use and measure the proper amount of this medicine for your child. It is best to give Entrogyl Syrup on an empty stomach. In case of an upset stomach, combine it with food. Ensure to complete the entire course even if your child starts feeling well. Keep the container tightly closed and keep away from pets. Consult your doctor if your child's condition is not improving or getting worse after taking few doses of this medicine.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Effect on sleep is not established

How it works
Entrogyl Syrup is composed of Norfloxacin and Metronidazole. Metronidazole interferes with the DNA of the bacterial cell and thereby stops the protein synthesis processes. Norfloxacin stops the action of a bacterial enzyme called DNA-gyrase. This helps to kill or prevent the growth of bacteria in the body.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Quinolones, Anthelmintics, Antibiotics

Schedule

Schedule H

Drugs, H., 2021. Metronidazole: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 22 June 2021].

https://medlineplus.gov/druginfo/meds/a689011.html>

Pch.health.wa.gov.au. 2021. [online] Available at: < [Accessed 22 June 2021].

https://pch.health.wa.gov.au/-/media/Files/Hospitals/PCH/General-documents/Health-professionals/ChAMP-Monographs/Norfloxacin.PDF>

Medicines.org.uk. 2021. Metronidazole Rosemont 200mg/5ml Oral Suspension - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 1 October 2021].

https://www.medicines.org.uk/emc/product/6690/smpc#gref>
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Information on this page was last updated on 2 Nov 2021

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