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Endoxan N 1000 mg Injection

Manufactured byZydus Cadila
Description

Endoxan N 1000 mg Injection is an anticancer agent that is used alone or in combination with other medications for the treatment of different types of malignant cancers. Close monitoring of kidney function and the blood cell count is necessary while receiving this medication.

Side effects

Major & minor side effects for Endoxan N 1000 mg Injection

  • Black or tarry stools
  • Pain at the injection site
  • Hair loss
  • Fever and chills
  • Weakness
  • Loss of appetite
  • Nausea and Vomiting
  • Diarrhea
  • Headache
  • Increased sweating
  • Skin rash

Uses of Endoxan N 1000 mg Injection

What is it prescribed for?

  • Malignant cancers
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women.

Allergy

This medicine is not recommended for use in patients with a known allergy to Cyclophosphamide, other alkylating agents, or any other inactive ingredients present along with the formulation.

Urinary outflow obstruction

This medicine is not recommended for use in patients with urinary flow obstruction or cystitis (inflammation of the urinary bladder) due to the increased risk of worsening of the patient's condition.

Bone marrow suppression

This medicine is not recommended in patients with severe bone marrow suppression (decrease in the production of blood cells).
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women.
General warnings

Secondary malignancies

This medicine may increase the risk of secondary tumors. Most frequently, the urinary tract, thyroid gland, and blood are affected. Close monitoring of signs and symptoms is necessary. Therapy should be discontinued if malignancy develops.

Blood cell count

The use of this medicine is known to lower the count of white blood cells (neutrophils) and platelets. Close monitoring of complete blood cell counts is necessary before and during therapy with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Lung diseases

This medicine should be used with caution in patients with a history of lung diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Infections

This medicine should be used with caution due to the increased risk of severe and potentially life-threatening infections. Report any unusual symptoms such as a fever, diarrhea, sore throat, pain or burning during urination, etc. to the doctor immediately. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients suffering from liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery

This medicine may cause dizziness, drowsiness, weakness, or tiredness in some patients. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Diltiazem

Warfarin

Live attenuated vaccines and related products

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. It should be given in multiple cycles along with other chemotherapy agents. It is important to receive every scheduled dose. The blood cells count and kidney function should be assessed before starting the treatment. Any signs and symptoms of heart and lung dysfunction should be reported to the doctor on priority. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the cancer cells from multiplying and stops their growth.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Alkylating agents

Schedule

Schedule G

Cyclophosphamide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 16 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB00531

[Internet]. 2017 [cited 16 June 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/30163

DailyMed - Cyclophosphamide injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 16 April 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=520bfe39-dfd5-4a20-9a37-80078afded0d

Cyclophosphamide Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 1 June 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a611044.html

[Internet]. Accessdata.fda.gov. 2020 [cited 16 April 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012141s090,012142s112lbl.pdf
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Information on this page was last updated on 1 Jun 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.