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Endobloc T Kit Tablet
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Endobloc T Kit Tablet

Manufactured byCIPLA LTD
ContainsAmbrisentan (5 mg) + Tadalafil (20 mg)
Description
Endobloc T Kit Tablet is used in the treatment of pulmonary arterial hypertension (a condition characterized by high blood pressure inside the blood vessels that carry the blood from the heart to your lungs). Endobloc T Kit Tablet is a combination of Ambrisentan and Tadalafil. Ambrisentan works by stopping the action of a chemical substance in your body that causes narrowing of your blood vessels and prevents normal blood flow. Tadalafil works by relaxing the blood vessels in your lungs and allowing blood to flow more easily. Endobloc T Kit Tablet may cause common side effects such as headache, low red blood cell count, abdominal pain, constipation, chest pain, nasal congestion, etc. Consult your doctor if these symptoms persist or worsen. Endobloc T Kit Tablet should be taken exactly as directed by your doctor. Take it at the same time every day to maintain a constant level of this medicine in your body. Endobloc T Kit Tablet should be avoided if you are allergic to it. Inform your doctor if you have a history of heart, eye or ear problems before beginning treatment with this medicine. Close evaluation with respect to your current medicines is necessary to avoid any undesired side effects. Endobloc T Kit Tablet is not recommended for use in children below 18 years of age. If you are pregnant or breastfeeding, or are planning a pregnancy, consult your doctor before taking this medication.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Endobloc T Kit Tablet

  • Anaemia (Low red blood cell count)
  • Headache
  • Abdominal pain
  • Constipation
  • Flushing (reddening of the skin)
  • Chest pain and discomfort
  • Nasal congestion
  • Dizziness
  • Syncope (loss of consciousness)
  • Hypotension (low blood pressure)
  • Increased liver enzyme levels

Uses of Endobloc T Kit Tablet

What is it prescribed for?

  • Pulmonary arterial hypertension
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Endobloc T Kit Tablet begins to show its effect within 30 to 45 minutes after intake.
  • How long do the effects of this medicine last?
    Endobloc T Kit Tablet remains effective for an approximate duration of three days after intake.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Endobloc T Kit Tablet due to the increased risk of low blood pressure. Inform your doctor if you experience any symptoms of headache, dizziness, lightheadedness, fainting, changes in your pulse or heart rate.
  • Is this a habit forming medicine?
    No habit-forming tendencies have been reported with Endobloc T Kit Tablet.
  • Can this medicine be taken during pregnancy?
    Endobloc T Kit Tablet may cause severe side effects in your developing foetus and is not recommended for use during pregnancy.
  • Can this medicine be taken while breast-feeding?
    It is not known if Endobloc T Kit Tablet passes into breastmilk. This medicine is not recommended for use during breastfeeding.

Allergy

Avoid Endobloc T Kit Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Loss of vision

Endobloc T Kit Tablet may affect your vision and is not recommended if you have lost vision in one of your eyes.

Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a chronic (long-term), progressive condition that affects your lungs and may cause fibrosis (scarring) in your lungs. This may result in breathing difficulties. Endobloc T Kit Tablet is not recommended if you have idiopathic pulmonary fibrosis due to the increased risk of worsening your condition.
Warnings for special population

Pregnancy

Endobloc T Kit Tablet may cause severe side effects in your developing foetus and is not recommended for use during pregnancy.

Breast-feeding

It is not known if Endobloc T Kit Tablet passes into breastmilk. This medicine is not recommended for use during breastfeeding.
General warnings

Use in children

Endobloc T Kit Tablet is not recommended for use in children below 18 years of age due to a lack of safety and efficacy studies.

Driving or Operating machines

Endobloc T Kit Tablet may cause dizziness and hypotension (low blood pressure). Do not drive vehicles or operate machines if you experience any symptoms that may affect your mental alertness after taking this medicine.

Other medicines

Endobloc T Kit Tablet may interact with other medicines and may cause undesired side effects. Inform your doctor about your current medicines including any herbs or supplements before taking this medicine.

Anaemia

Endobloc T Kit Tablet may lower the haemoglobin (a protein present in your red blood cells) and haematocrit levels (a measure of the percentage of your red blood cells) in your body. This may increase your risk of anaemia (low red blood cell count). Your haemoglobin level and red blood cell count needs to be closely monitored.

Fluid retention

Endobloc T Kit Tablet may increase your risk of fluid retention (accumulation of fluid in your body tissues and cavities). Symptoms may include swelling of affected parts of your body (feet, ankles and hands), rapid weight gain (over a few days or weeks), etc. Inform your doctor if you experience such symptoms.

Fertility

Endobloc T Kit Tablet may lower your sperm cell count and affect your fertility. Hence it is recommended to avoid planning a pregnancy while on treatment with this medicine.

Women of childbearing potential

Endobloc T Kit Tablet may cause severe side effects in the developing foetus. Hence it is recommended to avoid pregnancy while on treatment with Endobloc T Kit Tablet and for one month after discontinuation of treatment with this medicine.

Missed Dose

Try not to skip a dose of Endobloc T Kit Tablet. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double the dose to compensate for a missed one.

Overdose

Do not take more than the prescribed dose. Contact your doctor if you suspect an overdose with Endobloc T Kit Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Endobloc T Kit Tablet due to the increased risk of low blood pressure. Inform your doctor if you experience any symptoms of headache, dizziness, lightheadedness, fainting, changes in your pulse or heart rate.
Interaction with Medicine

Azole antifungal agents

Antihypertensives

Riociguat

Nitrates

Cyclosporine

Disease interactions

Heart Disease

Endobloc T Kit Tablet should be used with caution if you have pre-existing heart problems due to the increased risk of severe side effects. Your blood pressure, electrocardiogram (ECG), electrolyte levels need to be closely monitored to assess your heart function while on treatment with this medicine.

Eye disorder

Endobloc T Kit Tablet may affect your vision and increase your risk of vision loss. Inform your doctor if you experience any changes in your vision while on treatment with this medicine.

Hearing impairment

Endobloc T Kit Tablet may increase your risk of side effects such as tinnitus (a ringing sensation in your ears), hearing loss, etc. Inform your doctor if you experience a sudden decrease or loss of hearing while on treatment with this medicine.

Priapism

Endobloc T Kit Tablet may increase your risk of priapism, a condition with a prolonged, painful erection of your penis. Inform your doctor if you experience an erection lasting longer than four hours (with/without pain) while on treatment with this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Endobloc T Kit Tablet with or without food. Do not take more or less than the prescribed dose. Do not stop the use of this medicine without consulting your doctor as it may worsen your condition. Endobloc T Kit Tablet may cause anaemia (low red blood cell count). Your red blood cell count needs to be closely monitored. Avoid alcohol consumption while on treatment with Endobloc T Kit Tablet as it may affect your blood pressure. Do not drive vehicles or operate machines if you experience any symptoms that may affect your alertness after taking Endobloc T Kit Tablet.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Endobloc T Kit Tablet is a combination of Ambrisentan and Tadalafil. Ambrisentan works by stopping the action of endothelin, a chemical substance in your body that causes narrowing of your blood vessels and prevents normal blood flow. Blocking of endothelin results in improved blood flow to your lungs. Tadalafil works by relaxing the blood vessels in your lungs and allowing blood to flow more easily.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antihypertensive combinations

Schedule

Schedule H

CiplaMed. 2021. ENDOBLOC T Kit. [online] Available at: < [Accessed 7 December 2021].

https://ciplamed.com/content/endobloc-t-kit>

Drugs, H., 2021. Ambrisentan: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 7 December 2021].

https://medlineplus.gov/druginfo/meds/a612023.html>

Drugs, H., 2021. Tadalafil: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 7 December 2021].

https://medlineplus.gov/druginfo/meds/a604008.html>
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Information on this page was last updated on 24 Dec 2021

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