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Endace-160 Tablet
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Endace-160 Tablet

Manufactured bySAMARTH LIFE SCIENCES PVT LTD
ContainsMegestrol Acetate
Description
The primary ingredient of Endace-160 Tablet is available as an oral suspension and oral tablets. The oral suspension form of this medicine is used for the treatment of loss of appetite and weight loss in patients with acquired immunodeficiency syndrome (AIDS). The oral tablets are used in the palliative treatment of advanced breast cancer and advanced endometrial cancer (cancer that arose from the lining of the uterus). This medicine is not recommended for use in children.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Endace-160 Tablet

  • Sleeplessness
  • Rash
  • Sweating
  • Diarrhea
  • Indigestion
  • Mood swings
  • Weight gain
  • Nausea
  • Vomiting
  • Increase in blood pressure
  • Increased thirst

Uses of Endace-160 Tablet

What is it prescribed for?

  • Anorexia Nervosa
  • Cachexia
  • Breast cancer
  • Endometrial cancer
  • Unexplained Weight Loss
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is recommended for use in pregnancy only if the need is clinically established. Consult your doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

Allergy

This medicine is not recommended for use in patients with a known allergy to megestrol acetate or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnancy only if the need is clinically established. Consult your doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings

Vaginal bleeding

Use of this medicine may increase the risk of vaginal bleeding in women. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Report any unusual symptoms to the doctor on priority.

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of alterations in blood glucose levels. Regular monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Prophylactic therapy for weight loss

This medicine is not recommended as prophylactic therapy for weight loss and also as a diagnostic test for pregnancy.

Adrenal insufficiency

This medicine may increase the risk of adrenal insufficiency in some patients on therapy or being withdrawn from long-term therapy with this medicine.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of worsening of the patient's condition. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Fluid retention

This medicine should be used with caution in patients having a fluid retention disorder or are exposed to the risk factors due to the increased risk of worsening of the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Retinal thrombosis

Use of this medicine can cause a disturbance in vision and other problems in the eyes. It should be used with caution in patients suffering from a pre-existing eye disease. Use of this medicine should be stopped immediately if a visual disturbance is observed.

Missed Dose

Take/consume the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Thalidomide

Darunavir

Efavirenz

Glimepiride

Cyclosporine

Dofetilide

Disease interactions

Thromboembolism

This medicine is not recommended for use in patients with thromboembolism (a clotting disorder in which the formed clot moves from one place and lodges in another place) since it may worsen the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus since it may cause glucose intolerance. Regular monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take/consume this medicine with or without food. Do not take/consume in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking/consuming the medicine before completion of the course/without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by interfering with the hormonal balance in the body, which may stop the growth of cancer cells. It also increases appetite.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Hormones/antineoplastics, Progestins

Schedule

Schedule H

Megestrol acetate - DrugBank [Internet]. Drugbank.ca. 2018 [cited 27 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00351

Megestrol acetate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 27 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/megestrol_acetate

Megace 160 mg Tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 27 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/910#

Megestrol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 27 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682003.html

DailyMed - Megestrol Acetate- megestrol acetate tablet [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 27 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ff650c9-5665-4fa3-8163-f8eed8dcb1bd
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Information on this page was last updated on 7 May 2019

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