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Duvanta NP-20 Tablet

Manufactured byINTAS PHARMACEUTICALS LTD
ContainsDuloxetine (20 mg) + Methylcobalamin (0.5 mg)
Description

Duvanta NP-20 Tablet is a combination medicine which may be used to treat the symptoms of depression and other pain disorders. It should be used with caution in adults and children due to the risk of suicidal thoughts.

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Side effects

Major & minor side effects for Duvanta NP-20 Tablet

  • Nausea and vomiting
  • Diarrhea
  • Decreased appetite
  • Dizziness
  • Headache
  • Skin rash
  • Chest pain and discomfort
  • Fatigue
  • Sleepiness
  • Dry mouth
  • Abnormal ejaculation
  • Loose stools
  • Shaking of hands or feet
  • Heartburn

Uses of Duvanta NP-20 Tablet

What is it prescribed for?

  • Peripheral Neuropathy (nerve disorder)
  • Major depressive disorder
  • Generalized anxiety disorder
  • Chronic Musculoskeletal Pain
  • Fibromyalgia
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 3 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during the treatment with this medicine due to the increased risk of liver injury. Monitoring of liver enzymes is necessary. Any symptoms of abdominal pain, yellow discoloration of skin and eyes should be reported to the doctor on priority.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Leber's Disease

This combination medicine is not recommended for use in patients who have Leber's Disease, a rare genetic disorder due to the increased risk of worsening of the patient's condition.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

Allergy

This combination medicine is not recommended for use in patients with a known allergy to Duloxetine, methylcobalamin, or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Elderly

Few elderly patients may have a reduced capacity to absorb this medicine through the intestine. Appropriate dose adjustments and frequent clinical monitoring are necessary for such patients.

Other medicines

Many medicines interact with this medicine and may decrease the absorption of this medicine. Hence, it is advised that you report to the doctor all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Gastrointestinal surgery

Patients who have had a recent gastrointestinal surgery may have reduced absorption of this medicine. Appropriate dose adjustments should be done under your doctor's supervision.

Orthostatic Hypotension and fall

Use of this medicine is known to cause orthostatic hypotension especially during the 1st week of the treatment. This effect can increase the risk of fall in the elderly population. Any symptoms of dizziness, unsteady walking should be reported to the doctor. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Abnormal bleeding

Use of this medicine may increase the risk of bleeding especially in the patients receiving nonsteroidal anti-inflammatory drugs, aspirin, and warfarin. Monitoring of blood cells count should be performed. Any symptoms of abnormal bleeding should be reported to the doctor.

Low sodium levels

Use of this medicine is known to lower the sodium levels in the body. This risk is more in the elderly population and in the patients receiving diuretics. Monitoring of sodium levels should be performed. Any symptoms of unsteadiness, headache, difficulty in concentration should be reported to the doctor o priority.

Drug Withdrawal

Abrupt discontinuation of this medicine may increase the risk of adverse effects, especially if you have been using a high dose for a long duration. A gradual dose reduction is recommended to avoid these reactions. Do not stop the use of this medicine without consulting your doctor.

Skin reactions

Use of this medicine is known to cause rare but serious skin reactions like erythema multiforme and Stevens-Johnson Syndrome. Discontinue the treatment and inform the doctor if symptoms like itching, peeling skin, rashes appear.

Liver Disease

This medicine should be used with caution in patients with liver disease due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with extreme caution in patients with kidney disease due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Suicidal thoughts

This medicine should be used with caution due to the increased risk of suicidal tendencies. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during the treatment with this medicine due to the increased risk of liver injury. Monitoring of liver enzymes is necessary. Any symptoms of abdominal pain, yellow discoloration of skin and eyes should be reported to the doctor on priority.
Interaction with Medicine

Ciprofloxacin

Aspirin

Hydrochlorothiazide

Dextromethorphan

Disease interactions

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of alteration in the blood glucose levels. Close monitoring of blood glucose levels, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with glaucoma due to the risk of an increase in the fluid pressure in the eye. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take this medicine in larger or smaller quantities than recommended. The treatment should be started at lower doses and increase the dose gradually based on the response. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Duloxetine works by increasing the levels of certain chemical substances in the brain and thus helps in relieving the depressive symptoms. Methylcobalamin works by facilitating the enzymes responsible for the production of vital components and energy inside a cell.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Serotonin-norepinephrine reuptake inhibitors, Vitamins

Schedule

Schedule H

[Internet]. 2017 [cited 11 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/15694

Duloxetine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 11 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a604030.html#overdose

DailyMed - Duloxetine hydrochloride capsule, delayed release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 11 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a541d20-5466-433b-a104-40a7b2296076#Section_14.4

B12 V. Vitamin B12: MedlinePlus Medical Encyclopedia [Internet]. Medlineplus.gov. 2017 [cited 9 March 2017]. Available from:

https://medlineplus.gov/ency/article/002403.htm

Methylcobalamin hydrate | C63H93CoN13O15P - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 9 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/91886214#section=Top
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Information on this page was last updated on 26 Jun 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.