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Durart-R 450 Tablet
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Durart-R 450 Tablet

Manufactured byMylan Pharmaceuticals
ContainsDarunavir (400 mg) + Ritonavir (50 mg)
Description
Durart-R 450 Tablet is a combination of Darunavir and Ritonavir. It is an antiviral medicine used for the treatment of human immunodeficiency virus (HIV) infection (a condition that occurs when the virus attacks the immune system and interferes with your body's ability to fight infections or diseases). Durart-R 450 Tablet will not cure HIV infection, but it will delay the progression of a chronic, potentially life-threatening condition known as acquired immunodeficiency syndrome (AIDS) and other HIV-related conditions. This medicine works by preventing the virus from multiplying. Durart-R 450 Tablet shows some side effects like nausea, vomiting, stomach pain, diarrhoea, headache, indigestion, dizziness, weakness, trouble sleeping, etc. Consult your doctor if they bother you for a longer time or worsen. Do not take this medicine if you are allergic to it. Durart-R 450 Tablet should be taken with food. Take it in the dose and duration prescribed by your doctor. Avoid taking more than the recommended dose as it may increase the risk of side effects. Take it every day at the same time to maintain a consistent level of this medicine in your blood. Do not discontinue this medication without consulting your doctor, as it may worsen your condition. Durart-R 450 Tablet may not be suitable for everyone. Inform your doctor if you have heart or liver problems, diabetes (high blood sugar levels), or any other health conditions. Also, inform your doctor about all your ongoing medications to avoid undesired effects. Consult your doctor if you are pregnant or are breastfeeding. If you have an HIV infection, it is not recommended to breastfeed, as the Human immunodeficiency virus (HIV) may transfer to the baby through breastmilk.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Durart-R 450 Tablet

  • Feeling of warmth or heat
  • Redness of the skin especially on the face and neck
  • Headache
  • Sweating
  • Weight loss
  • Confusion
  • Change in sense of taste
  • Dizziness
  • Mood or mental changes
  • Skin Rash
  • Stomach pain
  • Diarrhoea
  • Dry mouth
  • Nausea and Vomiting
  • Tiredness
  • Trouble sleeping

Uses of Durart-R 450 Tablet

What is it prescribed for?

  • HIV infection
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Durart-R 450 Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The effect of Durart-R 450 Tablet lasts for approximately 12 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Durart-R 450 Tablet.
  • Can this medicine be taken during pregnancy?
    Durart-R 450 Tablet is not recommended for use during pregnancy unless clearly needed. If you are pregnant, consult your doctor to understand the potential risks and benefits of taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Durart-R 450 Tablet is not recommended for use while breastfeeding. Also, women with HIV infection are not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.

Allergy

Avoid taking Durart-R 450 Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Drug interaction

CYP3A are liver enzymes responsible for the breakdown of various medicines such as Alfuzosin, Amiodarone, Rifabutin, Triazolam, Midazolam, Cisapride, Simvastatin, Lovastatin, Indinavir, Sildenafil, Voriconazole, Ranolazine, Lurasidone, Colchicine, Ergotamine, etc., in the liver. Durart-R 450 Tablet is not recommended for use if you are receiving medicines that are highly dependent on CYP3A enzymes for their breakdown in the liver. Combined use may increase the risk of alteration in the blood levels of these medications, which may cause serious and life-threatening reactions.

Severe liver disease

Durart-R 450 Tablet is not recommended for use if you have severe liver problems, as this medicine may cause liver toxicity and further worsen your condition.
Warnings for special population

Pregnancy

Durart-R 450 Tablet is not recommended for use during pregnancy unless clearly needed. If you are pregnant, consult your doctor to understand the potential risks and benefits of taking this medicine.

Breast-feeding

Durart-R 450 Tablet is not recommended for use while breastfeeding. Also, women with HIV infection are not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.
General warnings

Fat Redistribution

Durart-R 450 Tablet should be used with caution as it may cause fat gain or fat loss in the body. It may result in central obesity, buffalo hump (excess fat behind the neck), peripheral wasting (difficulty in moving an arm or leg or making any movement), facial wasting (fat loss in the cheeks and temples), breast enlargement, and cushingoid appearance (extra fat build up on the sides of the face and weight gain). Consult your doctor if you have any concerns.

Pancreatitis

Pancreatitis refers to the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Durart-R 450 Tablet should be used with caution as it may cause pancreatitis. The risk is especially higher if you have a history of pancreatitis.

Immune reconstitution syndrome

Changes in your immune system can occur when you start taking Durart-R 450 Tablet. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. It may cause an exaggerated response making the symptoms of infection worse. Inform your doctor if you develop any new symptoms after starting treatment with Durart-R 450 Tablet.

Osteonecrosis

Durart-R 450 Tablet should be used with caution as it may rarely cause osteonecrosis (the death of bone cells due to a lack of blood supply). Consult your doctor if you experience joint aches and pain, joint stiffness, or difficulty in movement

Missed Dose

Take the missed dose of Durart-R 450 Tablet as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. Contact your doctor in case of an overdose of Durart-R 450 Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Erythromycin

Fluoxetine

Midazolam

Cyclosporine

Alprazolam

Atorvastatin

Cisapride

Loperamide

Disease interactions

Liver Disease

Durart-R 450 Tablet should be used with caution if you have active liver problems as it may worsen your condition.

Diabetes

Diabetes is a condition in which your blood sugar levels are increased. Durart-R 450 Tablet should be used with caution if you have diabetes as it may alter your blood sugar levels. Monitor your blood sugar levels regularly while you are taking this medicine.

Heart Disease

QT prolongation is a condition in which your heart muscles take a longer time to recharge between a heartbeat. Durart-R 450 Tablet may cause QT prolongation hence, it should be used with caution if you have heart problems.

Bleeding disorders

Haemophilia is an inherited bleeding disorder in which the blood does not clot properly. Durart-R 450 Tablet should be used with caution if you have haemophilia due to the increased risk of excessive bleeding.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Durart-R 450 Tablet exactly as instructed by your doctor. Do not take in larger or smaller quantities than recommended. Your doctor may suggest tests to monitor your liver function during treatment with this medicine. Taking Durart-R 450 Tablet will not prevent the transmission of HIV to others. Hence, avoid having unprotected sexual intercourse or sharing razors or toothbrushes.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Durart-R 450 Tablet works by stopping the human immunodeficiency virus (HIV) from multiplying.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Protease inhibitors, Antiviral agents

Schedule

Schedule H

2022. [online] Available at: < [Accessed 2 March 2022].

https://www.prezista.com/>

Drugs, H., 2022. Darunavir: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 2 March 2022].

https://medlineplus.gov/druginfo/meds/a607042.html>

Dailymed.nlm.nih.gov. 2022. These highlights do not include all the information needed to use PREZISTA safely and effectively. See Full Prescribing Information for PREZISTA. PREZISTA (darunavir) tablet, for oral use Initial U.S. Approval: 2006. [online] Available at: < [Accessed 2 March 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d4aa9007-1afb-4486-b323-33aadcd0b933>

Drugs, H., 2022. Ritonavir: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 28 February 2022].

https://medlineplus.gov/druginfo/meds/a696029.html>

Medicines.org.uk. 2022. Norvir 100mg film-coated tablets (Great Britain) - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 28 February 2022].

https://www.medicines.org.uk/emc/medicine/22952#>
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Information on this page was last updated on 3 Mar 2022

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