Dulaglutide

Description

Dulaglutide is an antidiabetic medicine used in the treatment of type 2 diabetes in adult patients. Patients are advised to follow a strict diet and exercise regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients with type 1 diabetes and diabetic ketoacidosis.

Side effects

Major & minor side effects for Dulaglutide

  • Diarrhea
  • Decreased appetite
  • Lack or loss of strength
  • Stomach discomfort
  • Nausea
  • Vomiting
  • Abdominal pain
  • Fatigue

Uses of Dulaglutide

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to dulaglutide or any other inactive ingredients present along with it.

Medullary thyroid carcinoma

This medicine is not recommended for use in patients with a personal or family history of medullary thyroid carcinoma due to the increased risk of worsening of the patient’s condition.

Multiple endocrine neoplasia type 2

This medicine is not recommended for use in patients with a known history of multiple endocrine neoplasia type 2 since the safety and efficacy of this medicine have not been established for such patients.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Angioedema

This medicine may cause anaphylaxis and other hypersensitivity reactions, including angioedema, in some patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Gastroparesis

This medicine is not recommended for use in patients with gastroparesis due to the increased risk of serious adverse effects. An alternative treatment option may be necessary in some cases based on the clinical condition.

Concomitant use of Insulin or insulin secretagogues

Concomitant dosing of insulin or insulin secretagogues should be evaluated due to the risk of hypoglycemia (low blood sugar levels). Risk of severe fall in blood sugar levels should be considered during dosing.

Pancreatitis

This medicine should be used with caution in patients with pre-existing pancreatitis since it may worsen the patient's condition. Use should be discontinued immediately if symptoms of pancreatitis worsen.

Missed Dose

Administer the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
Interaction with Medicine

Atazanavir

Chlorothiazide

Ciprofloxacin

Acetazolamide

Bexarotene

Clozapine

Gatifloxacin

Disease interactions

Pancreatitis

This medicine should be used with caution and monitoring in patients with pre-existing pancreatitis. Treatment with this medicine should be discontinued immediately if symptoms worsen. An alternative treatment option may be necessary in such cases based on the clinical condition.

Renal Dysfunction

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Thyroid Carcinoma

This medicine is not recommended for use in patients with a personal or family history of medullary thyroid carcinoma and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2) due to the increased risk of worsening of the patient’s condition. An alternative treatment option should be considered in such cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer Dulaglutide injection with or without food. Do not administer in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by increasing the levels of some natural substances. This results in lowering of the blood glucose levels.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Incretin mimetics

Schedule

Schedule H

Dulaglutide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 7 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB09045

Dulaglutide Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 7 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a614047.html

[Internet]. Pi.lilly.com. 2018 [cited 7 September 2018]. Available from:

https://pi.lilly.com/us/trulicity-uspi.pdf

Trulicity 1.5 mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 7 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/3634/smpc

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Information on this page was last updated on 8 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.