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Duet (400/57 mg) Dry Syrup

Manufactured byLupin Ltd.
ContainsAmoxycillin (400 mg) + Clavulanic Acid (57 mg)
Duet (400/57 mg) Dry Syrup is a combination of Amoxycillin and Clavulanic acid. Duet (400/57 mg) Dry Syrup is used to treat bacterial infections of the lungs and airways, middle ear, sinuses, skin, teeth, and urinary tract. It is also used to treat multidrug-resistant Tuberculosis. This medicine is generally meant to be used in children. However, your doctor may prescribe this medicine to you if you cannot swallow the tablet or capsule. Duet (400/57 mg) Dry Syrup shows common side effects like nausea, vomiting, stomach pain, and skin rash. Usually, these side effects are self-limiting. Consult the doctor at the earliest if any of these side effects persist or bothers your child. Before giving this medicine to your child, inform your doctor if your child is allergic to any antibiotics. Duet (400/57 mg) Dry Syrup can be given to your child with food as it improves absorption and decreases the risks of stomach upset. Your child's doctor will decide the dose and frequency based on the severity of infection, body weight and age of your child. Also, ensure that you complete the course of treatment even if your child starts feeling better after taking a few doses. Duet (400/57 mg) Dry Syrup is safe for your child, however, do share your child’s entire medical history with the doctor, including any previous episode of allergy, heart problem, a blood disorder, birth defects, lung problem, stomach or intestinal problem, skin disorder, liver and kidney problems. This information is critical as it can help your paediatrician in planning an overall treatment and dose adjustments for your child.

Side effects

Major & minor side effects for Duet (400/57 mg) Dry Syrup

  • Allergic Skin Reaction
  • Diarrhoea
  • Fever
  • Skin yellowing
  • Easy bruising and bleeding
  • Tooth discoloration
  • Nausea or vomiting
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Black or tarry stools
  • Muscle or joint pain
  • Sleeplessness

Uses of Duet (400/57 mg) Dry Syrup

What is it prescribed for?

  • Acute otitis media
  • Sinusitis
  • Lower respiratory tract infection
  • Skin infections
  • Pharyngitis/Tonsilitis
  • Urinary tract infection
  • Multidrug resistant Tuberculosis
Read More

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Duet (400/57 mg) Dry Syrup starts working within 1-2 hours of administration.
  • How long do the effects of this medicine last?
    The effect of Duet (400/57 mg) Dry Syrup lasts for an average duration of 6-8 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    Duet (400/57 mg) Dry Syrup has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Duet (400/57 mg) Dry Syrup is only recommended for use in children.
  • Can this medicine be taken while breast-feeding?
    Duet (400/57 mg) Dry Syrup is only recommended for use in children.


Avoid administration of Duet (400/57 mg) Dry Syrup if your child is allergic to it. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.


Duet (400/57 mg) Dry Syrup should be avoided if your child has Cholestasis (a condition where the normal flow of bile from the liver is interrupted).

Liver dysfunction

Avoid using Duet (400/57 mg) Dry Syrup if your child has a history of liver problems associated with the use of this medicine or any other antibiotics.
Warnings for special population


Duet (400/57 mg) Dry Syrup is only recommended for use in children.


Duet (400/57 mg) Dry Syrup is only recommended for use in children.
General warnings


Duet (400/57 mg) Dry Syrup can cause diarrhoea because it may also kill the helpful bacteria in your child's stomach or intestine. Seek emergency medical help if your child gets diarrhoea by using this medicine.

Antibiotic resistance

Finish the entire course of treatment with Duet (400/57 mg) Dry Syrup, even if your child's condition gets better to avoid antibiotic resistance (bacteria develops the ability to overcome the antibiotic's ability to kill them).

Liver disease

Duet (400/57 mg) Dry Syrup may increase liver enzyme levels and cause liver swelling. If your child has liver problems, caution should be maintained while using Duet (400/57 mg) Dry Syrup due to the risk of liver damage. Your doctor may adjust the dose of this medicine and may closely monitor your child's liver functioning if required, based on the clinical conditions of your child.

Form of medication

Duet (400/57 mg) Dry Syrup is normally used for children. However, adultss who are unable to chew or swallow the solid form can use the liquid form under their doctor's supervision.

Missed Dose

If you forget to give a Duet (400/57 mg) Dry Syrup dose to your child, make sure that you remember to give your next dose on time. Do not give two doses together to make up for a forgotten dose.


Never give Duet (400/57 mg) Dry Syrup more than the prescribed dose. If you suspect that you might have given an overdose of this medicine and observing difficulty in the child, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol


Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.


Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine




Live vaccines

Disease interactions


Duet (400/57 mg) Dry Syrup can kill the helpful bacteria in your child's stomach or intestine and lead to diarrhoea. Therefore use this medicine with extreme caution in children with colitis (swelling of the inner lining of the colon).

Kidney diseases

Children with kidney problems need special consideration while taking Duet (400/57 mg) Dry Syrup due to the risk of kidney damage. Dose adjustment will be done by your doctor based on the clinical condition of your child.
Food interactions
Information not available.
Lab interactions
Information not available.
Give Duet (400/57 mg) Dry Syrup to your child with food to decrease the risk of stomach upset. Ensure that you complete the entire course of Duet (400/57 mg) Dry Syrup as abrupt stopping may cause recurrence of the infection, or cause another infection. Your child may have a bitter taste in the mouth after taking Duet (400/57 mg) Dry Syrup. Eating citrus fruits or fruit juices may help. Encourage your child to drink plenty of water in case diarrhoea develops as a side effect. Never give Duet (400/57 mg) Dry Syrup unless prescribed by the doctor. You must also never share your child’s medicine with anyone else even if they show similar symptoms. Avoid giving Duet (400/57 mg) Dry Syrup to treat the common cold and flu-like symptoms caused by viruses. Never save Duet (400/57 mg) Dry Syrup for future. It cannot be said whether the same medicine will work on future infections. Discard the medicine if the seal is broken or the appearance of the liquid changes. Stop Duet (400/57 mg) Dry Syrup immediately if your child develops an itchy rash, facial swelling, or breathing difficulty. Report to the doctor without any delay.

To be taken with food

To be taken as instructed by doctor

Effect on sleep is not established

How it works
Duet (400/57 mg) Dry Syrup is a combination of Amoxycillin and Clavulanic acid. Amoxycillin binds to certain specific receptors and prevents the formation of a necessary component for the cell wall building process. Clavulanic acid is effective against a specific species of bacteria that are resistant to other antibiotic medicines.
Legal Status







Beta-lactamase inhibitors, Aminopenicillins


Schedule H

Drugs, H., 2021. Amoxicillin and Clavulanic Acid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 20 May 2021].


Dailymed.nlm.nih.gov. 2021. DailyMed - AMOXICILLAN AND CLAVULANATE POTASSIUM tablet, film coated. [online] Available at: < [Accessed 20 May 2021].


Ca.gsk.com. 2021. [online] Available at: < [Accessed 31 May 2021].


Pubchem.ncbi.nlm.nih.gov. 2021. Clavulanic acid. [online] Available at: < [Accessed 20 May 2021].


Pubchem.ncbi.nlm.nih.gov. 2021. Amoxicillin. [online] Available at: < [Accessed 22 January 2021].

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Information on this page was last updated on 26 Oct 2021


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