Dronedarone

Description

Dronedarone is used to maintain normal heartbeats in patients with a recent episode of atrial flutter or atrial fibrillation (rhythm disorders of the atrium) which may be life-threatening. It reduces the risk of the need for hospitalization in patients with paroxysmal or persistent atrial flutter (AFL) or atrial fibrillation (AF).

Side effects

Major & minor side effects for Dronedarone

  • Diarrhea
  • Nausea and vomiting
  • Dizziness
  • Unusual tiredness and weakness
  • Chest pain or discomfort
  • Fainting
  • Indigestion
  • Skin rash
  • Stomach discomfort, upset or pain
  • Acid or sour stomach
  • Shortness of breath
  • Change in taste

Uses of Dronedarone

What is it prescribed for?

  • Atrial Fibrillation
  • Atrial Flutter
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to dronedarone or any other inactive ingredients present along with it.

Bradycardia

This medicine is not recommended for use in patients with a heart rate less than 50 beats per minute due to the risk of worsening of the patient's condition.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe liver impairment due to the risk of worsening of the patient's condition.

Heart block greater than first degree

This medicine is not recommended for use in patients with second or third-degree heart block due to the risk of worsening of the patient's condition.

Heart Failure

This medicine is not recommended for use in patients with heart failure and recent decompensation requiring hospitalization or NYHA Class IV heart failure due to the risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Other medicines

Dronedarone may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Pulmonary Toxicity

This medicine may cause severe lung injury which includes hypersensitivity pneumonitis and Interstitial Pneumonitis. Discontinue the treatment as soon as these symptoms appear until the exact cause is identified.

Liver impairment

This medicine should be used with extreme caution in patients with mild to moderate liver impairment due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver impairment.

Hypokalemia and Hypomagnesemia

This medicine when used with potassium-depleting diuretics, may increase the risk of low potassium (Hypokalemia) and low magnesium (Hypomagnesemia) blood levels. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in elderly population

This medicine should be used with extreme caution in elderly patients above 75 years of age due to the risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving and operating machinery

This medicine may cause symptoms such as dizziness, fainting, weakness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Escitalopram

Ondansetron

Ciprofloxacin

Alprazolam

Disease interactions

Hepatic Dysfunction

This medicine should be used with extreme caution in patients with mild to moderate liver impairment due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver impairment.
Food interactions
Consumption of grapefruit juice or grapefruit is not recommended while taking this medicine due to increased risk of irregular heartbeat. Any symptoms of irregular heartbeat should be reported to the doctor.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by reducing the hyperactivity of the heart muscles which helps the heart to beat normally.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Group III antiarrhythmics

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 11 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB04855

[Internet]. Medlineplus.gov. 2018 [cited 11 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a609034.html

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 11 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Dronedarone

[Internet]. Accessdata.fda.gov. 2018 [cited 11 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022425lbl.pdf

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Information on this page was last updated on 24 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.