Doxifluridine

Description

Doxifluridine is used to treat cancer of the stomach, colon, rectum, breast, uterus, cervix, and the bladder. It may also be used to treat certain other cancers. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Doxifluridine

  • Diarrhea
  • Nausea
  • Vomiting
  • Loss of appetite
  • Weakness
  • Change in vision
  • Headache
  • Skin Rash
  • Hair loss

Uses of Doxifluridine

What is it prescribed for?

  • Cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to doxifluridine or any other active ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking/receiving this medicine.
General warnings

Bonemarrow suppression

This medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Risk of infections

Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

Gastrointestinal disorders

This medicine should be used with caution in patients having a pre-existing disorder of the stomach or the intestine due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Forms

This medicine is available as an oral capsule and intravenous solution. The capsule form of this medicine is approved in India.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Vaccinations or immunization

Vaccinations with live or attenuated strains of micro-organisms should be avoided while receiving this medicine. Since this medicine may alter the effects of the vaccines, your doctor may advise you to postpone therapy with the medicine based on your clinical condition.

Missed Dose

Oral: Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose. Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Oral: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Fosphenytoin

Acenocoumarol

Budesonide

Chloramphenicol

Azathioprine

Carboplatin

Bevacizumab

Carmustine

Disease interactions

Renal Disease

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart disease

Usage of this medicine may increase the risk of heart-related complications. Hence, caution is advised while initiating the therapy in patients with any active heart condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral: Take this medicine exactly as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor. Injection: This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by slowing or stopping the growth of cancer cells in the body.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antineoplastics, Antimetabolites

Schedule

Schedule H

Doxifluridine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 4 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/doxifluridine

Doxifluridine - DrugBank [Internet]. Drugbank.ca. 2019 [cited 4 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB12947

[Internet]. Journals.sagepub.com. 2019 [cited 7 February 2019]. Available from:

https://journals.sagepub.com/doi/abs/10.1177/03008916970831s138

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Information on this page was last updated on 7 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.