Doxazosin

Description

Doxazosin is an antihypertensive medicine which is used to treat high blood pressure and relieve symptoms of Benign Prostatic Hypertrophy (prostate enlargement) such as painful urination or urinary urgency. This medicine should be used with caution since it may cause a temporary loss of consciousness due to the sudden decrease in blood pressure (syncope). This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Doxazosin

  • Hypersensitivity
  • Increased/Irregular heart rate
  • Jaundice
  • Unusual bleeding or bruising
  • Blood in urine
  • Respiratory tract infection
  • Urinary tract infection
  • Dizziness
  • Orthostatic Hypotension
  • Swelling of ankles or feet
  • Prolonged and painful erection

Uses of Doxazosin

What is it prescribed for?

  • Hypertension
  • Benign prostatic hyperplasia
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Concerns

Commonly asked questions

  • Onset of action
    The antihypertensive effect of this medicine can be observed within 1-2 hours of administration of the dose.
  • Duration of effect
    Doxazosin remains active in the body for up to 24 hours after administration.
  • Safe with alcohol?
    It is recommended that you do not consume alcohol while taking this medicine due to the increased risk of drowsiness, dizziness, very low blood pressure, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infants should be monitored closely for any adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to doxazosin or any other quinazolines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infants should be monitored closely for any adverse effects.
General warnings

Use in pediatrics

This medicine is not recommended for use in children.

CNS effects

Doxazosin may cause drowsiness and it may affect your thinking and judgment. Hence, it is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery, especially for 24 hours after the first dose or after increasing the dose of this medicine.

Syncope

This medicine should be used with caution due to the increased risk of temporary loss of consciousness caused by a sudden decrease in the blood pressure. Close monitoring of blood pressure may be necessary based on the clinical condition of the patient.

Missed Dose

If a dose of Doxazosin is missed, take the dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

It is recommended that you do not consume alcohol while taking this medicine due to the increased risk of drowsiness, dizziness, very low blood pressure, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine. Report any incidence of breathing difficulty or dizziness to the doctor immediately.
Interaction with Medicine

Tizanidine

Sodium oxybate

Mixed grass pollens allergen extract

Disease interactions

Hypotension

This medicine should be used with caution in patients with a known history of hypotension or patients on high blood pressure medicines due to the increased risk of a sudden drop in blood pressure and loss of consciousness. Report any symptoms such as dizziness, lightheadedness, headache, increased or decreased heart rate, or fainting to the doctor immediately. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine. Appropriate dose adjustments may be necessary based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients with a known history of liver disease or active liver disease due to the increased risk of adverse effects. Close monitoring of liver functions may be necessary for such patients while taking this medicine. Appropriate dose adjustment or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Use Doxazosin only for the conditions specified by the doctor. Do not take this medicine in larger amounts than prescribed or share this medicine with others. Report to the doctor all your medical conditions and current medicines including herbs and supplements before taking this medication. Report any undesired effects or lack of improvement to the doctor on priority.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by relaxing the blood vessels. This allows the blood to flow smoothly and decreases the blood pressure. It also relaxes the muscles of the prostate gland and relieves the symptoms of patients with benign prostatic hyperplasia (BPH).
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiadrenergic agents, peripherally acting, Alpha-blockers

Schedule

Schedule H

DailyMed - DOXAZOSIN- doxazosin mesylate tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 3 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ed04255-7d9c-464c-bfa6-c355755862d8&audience=consumer

Doxazosin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 3 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a693045.html

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 3 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~XtVQKR:4

Doxazosin [Internet]. Snomedbrowser.com. 2017 [cited 3 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/372508002

DBGET Search Result: All databases doxazosin [Internet]. Genome.jp. 2017 [cited 3 August 2017]. Available from:

http://www.genome.jp/dbget-bin/www_bfind_sub?

[Internet]. 2017 [cited 3 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.27911.latest.pdf

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Information on this page was last updated on 10 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.