Dorzolamide

Description

Dorzolamide is used in the treatment of increased pressure in the eye and open-angle glaucoma, a condition which may lead to eventual vision loss.

Side effects

Major & minor side effects for Dorzolamide

  • Stinging, burning, or discomfort in the eye
  • Sensitivity to light
  • Bitter taste
  • Upset stomach
  • Itching eyes
  • Redness or swelling of eyes
  • Watery eyes
  • Skin rash
  • Headache
  • Nausea

Uses of Dorzolamide

What is it prescribed for?

  • Intraocular hypertension
  • Open-angle glaucoma
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 8 to 12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to dorzolamide or any other ingredients present along with it.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (creatinine clearance less than 30ml/min) due to the increased risk of severe side effects on the kidneys.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Liver disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe side effects. Any unusual symptoms should be reported to the doctor on priority.

Bacterial keratitis

If the ophthalmic solution of this medicine is contaminated by bacteria, it can lead to an infection of the cornea (bacterial keratitis). Patients are advised to take all hygienic precautions to ensure that the medicine is not contaminated.

Corneal edema

This medicine should be used with caution since it increases the risk of corneal edema. Any swelling of the eye should be reported to the doctor immediately.

Missed Dose

The missed dose should be administered as soon as possible. It is advisable to skip the missed dose if it is almost time for your next scheduled dose. Do not instill a double dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aspirin

Oral carbonic anhydrase inhibitors

Bismuth subsalicylate

Disease interactions

Bone marrow suppression

This medicine should be used with caution in patients with a previous history of blood cell disorders or bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of complete blood counts is necessary for such patients, especially with prolonged therapy. Report any symptoms such as fever, sore throat, bleeding, pallor, or dizziness to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Porphyria

This medicine should be used with extreme caution in patients with porphyria due to the increased risk of an acute attack of porphyria. These patients should be closely monitored for any unusual symptoms. Seek emergency medical treatment if any symptoms such as severe abdominal pain, muscle pain, extreme weakness, anxiety, red or brown urine, etc. appear.
Food interactions
Information not available.
Lab interactions
Information not available.
Use this medicine as per the instructions on the label or the package insert. Do not instill in larger amounts than prescribed. Seek emergency medical treatment in case of any side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. If you are using any other eye drops, maintain a time gap of at least 5 to 10 minutes between administering the two eye drops.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Dorzolamide reduces the fluid pressure in the eye.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Ophthalmic glaucoma agents, Carbonic anhydrase inhibitors

Schedule

Schedule N/A

DailyMed - DORZOLAMIDE HCL- dorzolamide hydrochloride solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 8 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f00ee361-51ed-48aa-bf34-2df0af2e2ac3

Dorzolamide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 8 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00869

Dorzolamide Ophthalmic: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a697049.html

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 8 August 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 8 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~gdANKa:1

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Information on this page was last updated on 15 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.