Doripenem

Description

Doripenem is an antibiotic used to treat a variety of infections caused by bacteria such as infections in the stomach and the urinary tract. It should be used with caution in patients with seizures and kidney disease.

Side effects

Major & minor side effects for Doripenem

  • Diarrhea
  • Pale skin
  • Difficulty in breathing
  • Decreased urine output
  • Loss of appetite
  • Swelling of face and feet
  • Headache

Uses of Doripenem

What is it prescribed for?

  • Intraabdominal Infection
  • Urinary Tract Infection
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Concerns

Commonly asked questions

  • Onset of action
    The time required by this medicine to show its effect in the body is not clinically established. However, it takes 1 hour to reach the maximum concentration in the blood after a 500 mg injection.
  • Duration of effect
    The time until which this medicine remains active in the body is not clinically established. However, it remains in the body for an average duration of 2 days.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is recommended for use in pregnant women only if necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is recommended for use in breastfeeding women only if necessary. Monitoring of the infants for any undesired effects like diarrhea or thrush is necessary if this medicine is used in breastfeeding women.

Allergy

This medicine is not recommended for use in patients with a known allergy to Doripenem and other medicines belonging to the beta lactam antibiotics.
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnant women only if necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is recommended for use in breastfeeding women only if necessary. Monitoring of the infants for any undesired effects like diarrhea or thrush is necessary if this medicine is used in breastfeeding women.
General warnings

Diarrhea

Doripenem should be used with caution due to the increase in the risk of diarrhea. The risk is especially higher in patients with a history of gastrointestinal diseases. Report any history of gastrointestinal diseases to the doctor before receiving this medicine. Any symptoms like diarrhea, blood in stools, etc. should be reported to the doctor on priority. Close monitoring of fluids and electrolytes levels is necessary while receiving this medicine.

Drug-resistance

Usage of Doripenem without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Pediatric use

The safety and efficacy of Doripenem is not established in children less than 18 years of age.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Sodium Valproate

Ethinyl Estradiol

Live cholera vaccine

Disease interactions

Central nervous system disorders

This medicine should be used with caution in patients with a history of central nervous system disorders due to an increased risk of side effects like seizures. Inform the doctor if you have any history of seizures before receiving this medicine. The dose of Doripenem should be adjusted and a suitable antiseizure medicine should be considered based on the clinical condition.

Impaired kidney function

This medicine should be used with caution in patients with a history of kidney diseases. Close monitoring of kidney function is necessary while receiving this medicine. The dose of this medicine should be adjusted based on the degree of kidney dysfunction.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Doripenem as advised by the doctor. Do not administer larger quantities than prescribed by the doctor. Consult the doctor if you experience any undesirable effects. Do not stop treatment with the medicine before completion of the course.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Doripenem is a broad-spectrum antibiotic which works by interfering with the bacterial cell wall synthesis.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Carbapenems

Schedule

Schedule H

DailyMed - DORIPENEM- doripenem powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fea0fab5-d29a-47ce-b34e-d6033aa9ca66

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 24 July 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 24 July 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2

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Information on this page was last updated on 27 Jul 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.