Doripenem
Description
Doripenem is an antibiotic used to treat many bacterial infections of the stomach, urinary tract, lungs, etc. This medicine works by killing the bacteria that causes infection by interfering with its cell wall formation.
Doripenem shows side effects like skin rashes, headache, nausea, diarrhoea and pain at the site of injection. Most of these side effects resolve with time as your body adapts to the medicine. However, if any of these side effects persist or worsen, consult your doctor immediately. Do not use this medicine if you are allergic to it.
Doripenem is given in the hospital setting by a drip or into the veins for 1 hour under the supervision of a healthcare professional in the clinical setting. It is infused slowly for 3 to 4 hours in patients with kidney disease or ventilator-associated pneumonia (patients with lung infection kept on a ventilator). Your doctor will decide the Doripenem dose to be administered based on the severity and location of the bacterial infection. Therefore, there are fewer chances of missing doses or overdose. Ensure to complete the course of this medicine even if there is an improvement.
Doripenem has to be used with caution in certain cases. Before taking this injection, inform your doctor if you have any problems of heart, liver and kidney or if you are under active medications. Inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding. Your doctor may suggest tests to monitor your liver and kidney function during the treatment with this medicine. This medicine is not recommended for use in children below 18 years of age.
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Side effects
Major & minor side effects for Doripenem
- Diarrhoea
- Pale skin
- Difficulty in breathing
- Decreased urine output
- Loss of appetite
- Swelling of face and feet
- Headache
- Pain at the injection site
- Swelling and redness at the injection site
- Nausea
Uses of Doripenem
What is it prescribed for?
- Stomach and Intestine Infection
- Urinary tract infections
- Lung Infection
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Concerns
Commonly asked questions
- Onset of actionThe exact time taken for Doripenem to show its effect is not known. However, you may start feeling well in the first few days after taking this medicine.
- Duration of effectThe average time for which Doripenem stays in the body is not known. However, it may stay up to 2 days in the body.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?Doripenem has no habit forming tendency.
- Usage in pregnancy?Doripenem is not recommended for use in pregnant women as the safety and efficacy data is not available. Consult your doctor before using this medicine if you are pregnant.
- Usage while breast-feeding?It is not known if Doripenem passes into the breastmilk or not. Hence, it is not recommended for use while breastfeeding. Consult your doctor before using this medicine. If you are prescribed this medicine while you are breastfeeding, your infant will be monitored for any undesired effects like diarrhoea or thrush.
Allergy
Do not use Doripenem if you have a known allergy to this medicine. Seek medical attention if you experience either skin rashes, hives (itchy, painful eruptions that sting), swelling (face, lips, tongue, etc.), or breathing difficulty, etc.
Warnings for special population
Pregnancy
Doripenem is not recommended for use in pregnant women as the safety and efficacy data is not available. Consult your doctor before using this medicine if you are pregnant.
Breast-feeding
It is not known if Doripenem passes into the breastmilk or not. Hence, it is not recommended for use while breastfeeding. Consult your doctor before using this medicine. If you are prescribed this medicine while you are breastfeeding, your infant will be monitored for any undesired effects like diarrhoea or thrush.
General warnings
Diarrhoea
As Doripenem is an anti-bacterial it kills the helpful bacteria in the intestine. sing this medicine may lead to more frequent diarrhoea and dehydration. While you are on this medication, your clinical condition and electrolytes levels will be closely monitored by your doctor. It is recommended that you drink enough healthy liquids to maintain your fluid level.
Antibiotic resistance
An incomplete course of Doripenem may cause antibiotic resistance (the ability of bacteria to oppose the effect of antibiotics). Ensure that you complete the entire course even if you start feeling well within few days.
Use in children
The safety and efficacy of Doripenem has not been studied in children less than 18 years of age. Hence, it is not recommended for use.
Missed Dose
Doripenem is given by healthcare professionals in a clinical setting, so the likelihood of missing a dose is very low.
Overdose
Doripenem is given by a healthcare professional, the possibility of an overdose is quite low. If an overdose is suspected, the doctor will initiate emergency medical treatment.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Live cholera vaccine
Sodium Valproate
Ethinyl Estradiol
Disease interactions
Central nervous system disorders
Doripenem is not safe for use in people with a history of central nervous system disorders as it increases the risk of side effects like seizures. Inform your doctor if you have any history of seizures before receiving this medicine.
Impaired kidney function
Doripenem is excreted through kidneys and an impaired kidney may increase the risk of accumulation of the medicine in your body. This may lead to other undesirable effects and also worsen your condition. Therefore, your doctor will suggest periodic tests to monitor your kidney function.
Food interactions
Information not available.
Lab interactions
Information not available.
Doripenem should be given only in a clinical set-up under the supervision of a doctor or a trained healthcare professional.
Inform your doctor if you are allergic to penicillin or are taking any medications for seizures before receiving this medicine.
Diarrhoea may occur as a side effect of this medicine. Inform your doctor if you experience stomach pain or find blood in your stool.
Your doctor may monitor the liver and kidney function during the treatment with this medicine.
Miscelleneous
How it works
Doripenem is an antibiotic that works by interfering with the bacterial cell wall (protective covering) formation, eventually killing them.
Legal Status
Classification
Category
Carbapenems
Schedule
Schedule H
Drugs, H., 2021. Doripenem Injection: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 16 July 2021].
Ema.europa.eu. 2021. [online] Available at: < [Accessed 16 July 2021].
Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 16 July 2021].
Information on this page was last updated on 27 Aug 2021
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.