Dolutegravir

Description

Dolutegravir is an antiviral medicine which is used in combination with other medicines to treat human immunodeficiency virus (HIV) infection. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Close monitoring of liver function is necessary while receiving this medicine.

Side effects

Major & minor side effects for Dolutegravir

  • Headache
  • Sleeplessnes
  • Black or tarry stools
  • Nausea and Vomiting
  • Weakness and general discomfort
  • Stomach pain
  • Dark urine
  • Loss of appetite
  • Weight gain
  • Yellow eyes or skin

Uses of Dolutegravir

What is it prescribed for?

  • HIV infection
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is recommended for use in breastfeeding women only in life-threatening conditions. The risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use if you have a known allergy to dolutegravir or any other ingredients present along with it.

Dofetilide

Use of Dolutegravir must be avoided in patients receiving dofetilide as it may increase the undesired effects of dofetilide which may lead to potentially serious and life-threatening side effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is recommended for use in breastfeeding women only in life-threatening conditions. The risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Liver diseases

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney Diseases

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Immune reconstitution syndrome

This medicine should be used with caution due to the increased risk of Immune reconstitution syndrome. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypersensitivity reactions

This medicine may cause severe allergic reactions such as skin rash, organ dysfunction, liver injury, etc. in some patients on therapy. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aluminium Hydroxide

Efavirenz

Phenytoin

Metformin

Dofetilide

Disease interactions

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver impairment due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Complete the course of treatment to prevent the spread of the infection.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Integrase strand transfer inhibitor

Schedule

Schedule H

Tivicay film-coated tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 26 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/5248/smpc#INDICATIONS

Dolutegravir - DrugBank [Internet]. Drugbank.ca. 2018 [cited 26 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB08930

Dolutegravir: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 27 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a613043.html

DailyMed - TIVICAY- dolutegravir sodium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 27 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=63df5af3-b8ac-4e76-9830-2dbb340af922

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Information on this page was last updated on 27 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.