Dobutamine

Description

Dobutamine is used for the treatment of heart failure caused due to a heart attack, heart muscle disease, or other heart disorders. It is also used to improve heart function in patients undergoing open heart surgery or on a ventilator. It is used only when other therapies are ineffective.

Side effects

Major & minor side effects for Dobutamine

  • Increased heart rate
  • Chest pain
  • Changes in blood pressure
  • Narrowing of blood vessels
  • Irregular heartbeat
  • Headache
  • Chest tightness
  • Shortness of breath
  • Increase in white blood cell count
  • Unusual bleeding or bruising
  • Increased urination frequency
  • Nausea
  • Skin rash and itching
  • Fever
  • Swelling and redness at the injection site
  • Fast and uncontrolled contractions of the ventricles
  • Restlessness
  • Shaking and trembling of arms and feet
  • Anxiety and confusion
  • Muscle cramps and stiffness

Uses of Dobutamine

What is it prescribed for?

  • Congestive Heart Failure
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Concerns

Commonly asked questions

  • Onset of action
    The effects of this medicine can be observed within 1 to 10 minutes of parenteral administration.
  • Duration of effect
    The effects of this medicine last for an average duration of 10 minutes.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding during treatment with this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to dobutamine, sodium metabisulphite, or any other inactive ingredients present along with it.

Obstructive heart disease

This medicine is not recommended for use in patients with a narrowing or obstruction in the heart or blood vessels that prevents the heart from filling or pumping blood properly due to the increased risk of worsening of the patient’s condition.

Hypovolemia

This medicine is not recommended for use in patients with a very low blood volume or an inadequate circulatory filling due to the increased risk of worsening of the patient’s condition.

Pheochromocytoma

This medicine is not recommended for use in patients with pheochromocytoma, a tumor of the adrenal glands that causes increased secretion of adrenal hormones, since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding during treatment with this medicine.
General warnings

Other medicines

Dobutamine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Use in elderly

This medicine should be used with caution and monitoring in elderly patients since the risk of adverse effects is significantly high. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Insulin

Formoterol

Salmeterol

Beta blockers

Glimepiride

Digoxin

Desvenlafaxine

Linezolid

Cimetidine

Metformin

Disease interactions

Asthma

This medicine should be administered with extreme caution in patients with asthma due to the increased risk of worsening of the patient’s condition. Formulations containing sodium metabisulfite should not be administered, particularly in patients with a known history of allergy to sulfites. An alternative treatment option should be considered based on the clinical condition of the patient.

Cardiac arrhythmias

This medicine should be administered with caution in patients with a heart rhythm disorder due to the increased risk of worsening of the patient’s condition. Appropriate corrective measures, dose adjustments, or more frequent clinical monitoring are required to safely use this medicine. An alternative treatment option may be considered based on the clinical condition of the patient.

Hypokalemia

This medicine should be administered with caution in patients with reduced levels of potassium in the blood (hypokalemia). Frequent monitoring of blood potassium levels with appropriate electrolyte replacement may be required in some cases based on the patient's clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by stimulating the muscles of the heart, resulting in improved blood flow.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Cardiac stressing agents, Catecholamines, Inotropic agents, Vasopressors

Schedule

Schedule H

[Internet]. Mhra.gov.uk. 2018 [cited 25 September 2018]. Available from:

http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1491541945386.pdf

[Internet]. Sandoz.ca. 2018 [cited 25 September 2018]. Available from:

https://www.sandoz.ca/sites/www.sandoz.ca/files/Dobutamine%20PMe_20111114.pdf

[Internet]. Medicines.org.uk. 2018 [cited 25 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6462.pdf?view=pil

DailyMed - DOBUTAMINE- dobutamine injection, solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 25 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cb842dc2-fb15-48f9-e4b1-ea4280db0199

Dobutamine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 25 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00841

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Information on this page was last updated on 25 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.