Divalproex

Description

Divalproex is an anticonvulsant that is used to control seizures and migraine headaches. Take this medicine at the same time regularly. Do not take this medicine if you have are suffering from impaired liver function.

Side effects

Major & minor side effects for Divalproex

  • Diarrhea
  • Confusion
  • Headache
  • Muscle pain
  • Unusual tiredness and weakness
  • Sleepiness
  • Anxiety
  • Blurred vision
  • Yellow colored eyes or skin
  • Weight gain
  • Acid or sour stomach
  • Skin rash
  • Forgetfulness
  • Irregular menstrual periods
  • Ear pain

Uses of Divalproex

What is it prescribed for?

  • Epilepsy
  • Mania
  • Migraine Prophylaxis
Read More
Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 2 hours for a delayed release tablet.
  • Duration of effect
    The effect of this medicine lasts for an average of 1 to 2 days.
  • Safe with alcohol?
    Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
  • Is it habit forming?
    No habit forming tendency has been reported
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women.
  • Usage while breast-feeding?
    This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.

Allergy

Do not take this medicine if you have a known allergy to Divalproex.

Liver disease

Do not take if you have any liver injury or a family history of liver injury.

Urea cycle disorders

Do not use in patients with urea cycle disorder (high ammonium levels in the blood) or family history of urea cycle disorder.

Mitochondrial disorders

Do not use in patients and in children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.
General warnings

Pancreatitis

Divalproex may cause Pancreatitis which is a serious life-threatening reaction. Discontinue the medicine if Pancreatitis is detected and an alternate medicine should be considered.

Bleeding disorder

Use with caution in patients with the bleeding disorder as it may cause Thrombocytopenia. Make necessary dosage adjustments or discontinue the medicine if this condition is identified.

Suicidal behavior

Divalproex may increase the risk of suicidal thoughts. It should be used with caution and prescription size should be limited in patients with depression or suicidal tendencies.

Pediatric use

Divalproex is not recommended in children less than 2 years of age due to the increased risk of liver injury.

Geriatric use

Use with caution in the elderly population as it may lead to dizziness. The safety and efficacy of this medicine in the prophylaxis of migraines is not established.

Impaired liver function

This medicine is not recommended in patients with liver injury or a family history of liver injury.

Impaired kidney function

Use with caution in the patients with the kidney injury. Suitable dose adjustments are to be made based on the clinical condition.

Missed Dose

If you miss a dose of Divalproex, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Use of Anticonvulsants with alcohol will increase the central nervous system and respiratory system depression.

Instructions

Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
Interaction with Medicine

Lamotrigine

Metoclopramide

Warfarin

Ethinyl Estradiol

Imipenem

Disease interactions

Depression

Divalproex should be given with caution in the patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Dose adjustments are to be made based on the outcomes in the patient.

Liver Disease

Divalproex is not recommended in patients with liver injury or a family history of liver injury. This risk is more in children less than 2 years of age. Liver function tests are to be performed before starting the treatment. Discontinue the medicine if any abnormality is identified.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Divalproex with or without food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor as it may cause seizures.
Miscelleneous

Food timings: Information not available

Administration time: Information not available

Sleep inducing: Information not available

How it works
It works by binding to the receptors in the brain and inhibits the excitation of brain cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Anticonvulsants

Schedule

SCHEDULE H

Divalproex sodium medical facts from Drugs.com [Internet]. Drugs.com. 2017 [cited 13 March 2017]. Available from:

https://www.drugs.com/mtm/divalproex-sodium.html

[Internet]. 2017 [cited 13 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/26124

DailyMed - DIVALPROEX SODIUM- divalproex sodium capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 13 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f911748c-fb3a-fe1a-ab2a-4b40455e05ef

Valproic Acid: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 13 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682412.html

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 13 March 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~qg7dLV:1

Search | Medscape [Internet]. Search.medscape.com. 2017 [cited 13 March 2017]. Available from:

http://search.medscape.com/search/?q=divalproex%20sodium

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Information on this page was last updated on 20 Mar 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.