Disulfiram

Description

Disulfiram is used to treat chronic alcoholism. It discourages the use of alcohol even in small amounts by causing unpleasant effects such as flushing of the face, vomiting, breathing difficulty, sweating, choking, and anxiety. These effects may start 10 minutes after consumption of alcohol and last for about 1 hour. This medicine only discourages drinking alcohol and is not a cure for alcoholism.

Side effects

Major & minor side effects for Disulfiram

  • Dark colored urine
  • Jaundice
  • Stomach pain
  • Loss of appetite
  • Change in taste/ Metallic taste
  • Headache
  • Fatigue

Uses of Disulfiram

What is it prescribed for?

  • Alcohol dependence
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2 to 12 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 2 weeks.
  • Safe with alcohol?
    Consumption of alcohol while on treatment with Disulfiram is not recommended since it will cause severe unpleasant side effects such as flushing of the face, vomiting, breathing difficulty, sweating, choking, and anxiety.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Hypersensitivity

This medicine is not recommended for use in patients with a known allergy to disulfiram or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Alcohol use

Do not consume alcoholic beverages or medicines containing alcohol for at least 12 hours before starting therapy with Disulfiram and for several weeks after stopping the therapy. Consumption of alcohol during this time period may cause severe side effects.

Drowsiness

This medicine may cause drowsiness or dizziness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery during treatment with this medicine.

Missed Dose

If you miss a dose of Disulfiram, take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact a doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol while on treatment with Disulfiram is not recommended since it will cause severe unpleasant side effects such as flushing of the face, vomiting, breathing difficulty, sweating, choking, and anxiety.
Interaction with Medicine

Leflunomide

Alcohol containing syrups

Paraldehyde

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Disulfiram as advised by your doctor. Do not take in larger amounts than advised or share this medicine with others. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. If you cannot swallow the tablet, crush it and mix it with water or milk for administration.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Disulfiram acts by producing unpleasant effects such as flushing of the face, vomiting, breathing difficulty, sweating, choking, and anxiety even if alcohol is consumed in a small quantity. These effects discourage the patient from drinking alcohol.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Drugs used in alcohol dependence, Alcohol antagonist, Acetaldehyde dehydrogenase inhibitors

Schedule

Schedule H

DailyMed - DISULFIRAM- disulfiram tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 8 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2361d16-94fc-43a9-8009-ed03dce0544f&audience=consumer

[Internet]. 2017 [cited 8 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.3048.latest.pdf

Disulfiram - DrugBank [Internet]. Drugbank.ca. 2017 [cited 8 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00822

MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682602.html

Disulfiram (substance) [Internet]. Snomedbrowser.com. 2017 [cited 8 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/387212009

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 8 August 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2017 [cited 8 August 2017]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2017-CMI-01341-1&d=2017080916114622483

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Information on this page was last updated on 15 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.