Disopyramide

Description

Disopyramide is an anti-arrhythmic medicine which is used to treat an irregular heartbeat. It belongs to a group of medicines called Class 1A antiarrhythmic agents.

Side effects

Major & minor side effects for Disopyramide

  • Dizziness
  • Fainting
  • Shortness of breath
  • Unusal tiredness
  • Blurred vision
  • Constipation
  • Dry eyes, mouth, nose or throat
  • Chest pain
  • Fast or slow heartbeat
  • Lightheadedness
  • Rash or Itching
  • Low blood sugar levels
  • Yellowing of skin or eyes

Uses of Disopyramide

What is it prescribed for?

  • Arrhythmias
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 min to 3.5 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 1.5 to 8.5 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.

Allergy

This medicine is not recommended for use if you have a known allergy to disopyramide or any other ingredients present along with it.

Cardiogenic shock

This medicine is not recommended for use in patients with cardiogenic shock due to the risk of worsening of the patient's condition.

Heart block greater than first degree

This medicine is not recommended for use in patients with second or third-degree heart block due to the risk of worsening of the patient's condition.

Congenital QT syndrome

This medicine is not recommended for use in patients with congenital QT syndrome due to the risk of worsening of the patient's condition.

Sick sinus syndrome

This medicine is not recommended for use in patients with sick sinus syndrome (heart rhythm disorder) due to the risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings

Electrolyte abnormalities

This medicine should be used with extreme caution in patients having an electrolyte imbalance in the body. An altered level of ions like magnesium and sodium affects the absorption of this medicine, reducing effectiveness. Hence, the electrolyte imbalance should be corrected in such patients before starting therapy with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition

Kidney impairment

This medicine should be used with extreme caution in patients with kidney impairment due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients with liver impairment due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypotension

This medicine may cause hypotension (low blood pressure) and hence should be used with caution in patients with low blood pressure due to increased risk of worsening of the patient's condition. Regular monitoring of blood pressure levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in elderly population

This medicine should be used with extreme caution in elderly patients due to the risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

QT Prolongation

This medicine may cause prolongation of the QT interval and worsen the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypoglycemia

This medicine may cause hypoglycemia (low blood sugar levels) in some patients. Regular monitoring of blood sugar levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving and operating machinery

This medicine may cause symptoms such as dizziness, fainting, blurred vision, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Ondansetron

Ciprofloxacin

Lidocaine

Amiodarone

Clarithromycin

Chlorpromazine

Disease interactions

Electrolyte imbalance

This medicine should be used with caution in patients having an electrolyte imbalance in the body. An altered level of ions like magnesium and sodium affects the absorption of this medicine, reducing effectiveness.

Heart disease

This medicine should be used with extreme caution in patients suffering from any heart disease that affects the blood pumping capacity and the normal rhythm. An alternate therapy should be considered based on the diagnosis made.
Food interactions
Consumption of grapefruit juice or grapefruit is not recommended while taking this medicine due to increased risk of adverse effects. Any unusual symptoms should be reported to the doctor immediately.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by modifying the electrical impulses in the heart, making it more resistant to abnormal activity.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Group I antiarrhythmics

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 10 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00280

[Internet]. Medlineplus.gov. 2018 [cited 10 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a682408.html

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d4d3d3ce-7986-4592-ae11-17d2b2008372&type=display

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/disopyramide

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Information on this page was last updated on 9 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.