All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcoholmoderate
Description - N/A
Instructions - Use of alcohol along with Diphenhydramine is not recommended since the combination increases the risk of side-effects like dizziness and drowsiness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol with this medicine.
Interaction with Medicine
Use of Diphenhydramine in patients with depression is not recommended since it may worsen the symptoms and may result in suicidal behavior or ideation. Patients with depression should be closely monitored for any changes in mood or behavior while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.
Renal and/or Liver diseasesmoderate
Patients with renal and/or liver diseases may be at higher risk of adverse effects during the treatment with this medicine. Appropriate dose adjustments and monitoring of kidney and liver function may be required based on the clinical condition.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.